摘要
目的观察超声引导聚桂醇硬化治疗甲状腺囊肿的效果及安全性。方法回顾性分析2016年1月至2019年9月南阳市中心医院收治的118例甲状腺囊肿患者的临床资料,患者均行超声引导下硬化治疗。根据治疗中硬化剂类型将118例患者分为聚桂醇组71例和无水乙醇组47例,治疗后随访12个月。比较两组治疗前后甲状腺囊肿体积变化及甲状腺功能指标[游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺激素(TSH)],比较两组的临床疗效及不良反应发生率。结果治疗后3、6、12个月,两组甲状腺囊肿体积均小于治疗前(P均<0.05),且两组同时间点囊肿体积及缩小率比较差异未见统计学意义(P>0.05)。治疗后6、12个月,两组FT3、FT4、TSH水平与治疗前比较差异均未见统计学意义(P均>0.05),且两组同时间点FT3、FT4、TSH水平比较差异未见统计学意义(P>0.05)。治疗后12个月,聚桂醇组总有效率(95.77%,68/71)与无水乙醇组(97.87%,46/47)比较差异未见统计学意义(P>0.05)。治疗后,聚桂醇组颈部刺激性疼痛(5.63%,4/71)、醉酒样反应(0,0/71)及不良反应发生率(9.86%,7/71)均低于无水乙醇组(17.03%,8/47;8.51%,4/47;31.91%,15/47),P均<0.05。结论聚桂醇用于甲状腺囊肿超声引导硬化治疗,与无水乙醇治疗效果相当,对甲状腺功能无不良影响,且聚桂醇治疗后不良反应更少。
Objective To observe the clinical efficacy and safety of ultrasound-guided lauromacrogol sclerotherapy in the treatment of thyroid cysts.Methods The clinical data of 118 patients with thyroid cysts admitted to Nanyang Central Hospital from January 2016 to September 2019 were retrospectively analyzed.All patients underwent ultrasound-guided sclerotherapy.According to the types of hardener during treatment,they were divided into lauromacrogol group(71 cases)and anhydrous ethanol group(47 cases),and they were followed up for 12 months after treatment.The changes of thyroid cyst volume,thyroid function indexes,including free triiodothyronine(FT3),free thyroxine(FT4)and thyroid stimulating hormone(TSH)before and after treatment were compared between the two groups;the clinical efficacy and incidence of adverse reactions were compared between the two groups.Results Three,6 and 12 months after treatment,the volumes of thyroid cyst in the two groups were smaller than those before treatment(all P<0.05),and there was no significant difference in cyst volume and reduction rate between the two groups at the same time point(P>0.05).Compared with preoperative levels,there was no significant difference in the levels of FT3,FT4 and TSH 6 and 12 months after treatment between the two groups(all P>0.05),and there was no significant difference in the levels of FT3,FT4 and TSH between the two groups at the same time point(P>0.05).There was no significant difference in the total effective rate between lauromacrogol group(95.77%,68/71)and anhydrous ethanol group(97.87%,46/47)12 months after treatment(P>0.05).After treatment,the incidence of neck irritation pain(5.63%,4/71),drunken like reaction(0,0/71)and adverse reactions(9.86%,7/71)in the lauromacrogol group were lower than those in the absolute ethanol group(17.03%,8/47;8.51%,4/47;31.91%,15/47),all P<0.05.Conclusions Lauromacrogol for ultrasound-guided sclerotherapy for thyroid cysts has equivalent effects to anhydrous ethanol,and it has no adverse effects on thyroid function and fewer adverse reactions after treatment.
作者
曹丽
相泓冰
杨静
郭满
Cao Li;Xiang Hongbing;Yang Jing;Guo Man(Department of Ultrasound Diagnosis,Nanyang Central Hospital,Nanyang 473000,China;Department of Thyroid Surgery,Nanyang Central Hospital,Nanyang 473000,China)
出处
《中国实用医刊》
2022年第10期38-41,共4页
Chinese Journal of Practical Medicine
关键词
甲状腺
囊肿
超声引导
硬化治疗
聚桂醇
无水乙醇
Thyroid gland
Cysts
Ultrasound-guided
Sclerotherapy
Lauromacrogol
Anhydrous ethanol
