摘要
透皮给药是将药物递送入皮肤从而达到治疗效果的一种给药方式。微针作为一种新型的透皮给药方式,具有成本低廉、便于自我给药、递送效率高等优点。但在微针中直接混入药物会造成药物释放过快、增加给药频率的问题。可降解介孔二氧化硅纳米颗粒(biodegradable mesoporous silica nanoparticles,b-MSNs)是一种广泛使用的无机药物载体,具有生物相容性好、可缓释药物等优点。因此提出了一种包封双氯芬酸钠(diclofenac sodium,DS)的b-MSNs的透明质酸微针即b-MSNs-DS透明质酸微针制备技术,并对b-MSNs-DS的表征以及微针的制备工艺、表征、生物相容性、抗炎效果、药物缓释效果、力学性能进行探究。b-MSNs-DS透明质酸微针可以缓释药物,从而较长时间内保持有效的药物浓度,解决了药物释放过快的问题。制备b-MSNs-DS透明质酸微针可以降低药物进入机体的吸收速率,长时间维持有效的血药浓度,从而降低给药频率,进而降低药物毒副作用,在临床医学中显示出巨大的前景。
The transdermal drug delivery was a way of delivering drugs into the skin to achieve therapeutic effects,as a new type of the transdermal drug delivery,the micro-needle had the advantages of low cost,easy self-administration,high delivery efficiency and so on.But directly putting the drug into micro-needle could cause rapidly drug release which led to add dosing frequency.Biodegradable mesoporous silica nanoparticles(b-MSNs)were widely used as an inorganic drug carrier,which had the advantages of good biocompatibility and sustained drug release.A preparation technology of hyaluronic acid microneedles encapsulating b-MSNs with diclofenac sodium(DS),namely b-MSNs-DS hyaluronic acid microneedles was proposed,and the preparation technology,representation,biocompatibility,anti-inflammatory effect were studied,drug release effect.The b-MSNs-DS hyaluronic acid micro-needle could release the drug slowly so that the effective drug concentration could be maintained for a long time,which solved the problem of drug releasing too fast.The preparation of b-MSNs-DS hyaluronic acid micro-needles could reduce the absorption rate of the drug into the body and maintain an effective blood drug concentration for a long time,thereby it reduced the frequency of administration,so reduced the toxic and side effects of the drug,which showed great prospects in clinical medicine.
作者
陈可欣
尚少梅
CHEN Kexin;SHANG Shaomei(School of Nursing,Peaking University,Beijing 100191,China)
出处
《新技术新工艺》
2022年第6期17-22,共6页
New Technology & New Process
基金
国家自然科学基金资助项目(81972158)
国家重点研发计划项目(2020YFC2008801)。
关键词
微针
可溶性
双氯芬酸钠
透明质酸
药物递送
二氧化硅
micro-needle
solubility
diclofenac sodium
hyaluronic acid
drug delivery
silicon dioxide
