摘要
目的探讨西尼必利联合多潘立酮治疗功能性消化不良患者的疗效及对胃动力的影响。方法选取2020年5月至2021年9月在东山县医院就诊的94例功能性消化不良患者为研究对象,按随机数字表法将患者分为对照组与试验组,每组47例。对照组采用多潘立酮治疗,试验组采用西尼必利联合多潘立酮治疗,比较两组临床疗效,治疗前后症状积分、生命质量、胃动力指标及用药安全性。结果试验组总有效率高于对照组,差异有统计学意义(P<0.05);治疗前,两组症状积分及简明健康状况量表(SF-36)评分比较,差异无统计学意义(P>0.05);治疗后,两组症状积分均低于治疗前,SF-36评分均高于治疗前,且试验组症状积分低于对照组,SF-36评分高于对照组,差异有统计学意义(P<0.05);治疗前,两组胃排空率、胃半排空时间比较,差异无统计学意义(P>0.05);治疗后,两组胃排空率均高于治疗前,胃半排空时间均短于治疗前,且试验组胃排空率高于对照组,胃半排空时间短于对照组,差异有统计学意义(P<0.05);两组用药不良反应总发生率比较,差异无统计学意义(P>0.05)。结论西尼必利联合多潘立酮治疗功能性消化不良患者的疗效显著,可提升患者生命质量,改善胃动力,且具有良好的用药安全性。
Objective To investigate the clinical effect of siniberide combined with domperidone in the treatment of functional dyspepsia.Methods From May 2020 to September 2021,94 patients with functional dyspepsia treated in our hospital were divided into a control group and an observation group according to the random number table method,47 cases in each group,the control group was treated with domperidone,and the observation group was treated with siniberide+domperidone,and the overall efficacy,pre-and post-treatment symptom integrals,quality of life,gastric motility indicators and drug safety of the two groups were observed and compared.Results The observation group(93.62%)of the total effective rate of treatment was significantly higher than that of the control group(76.60%),which was significantly higher(P<0.05);before treatment,there was no significant difference between the two groups of symptom scores and concise health questionnaire(SF-36)scores(P>0.05),and after treatment,the above indicator observation group improved more significantly than the control group(P<0.05);before treatment,the gastric emptying rate and gastric half emptying time were compared.There was no significant difference(P>0.05),and after treatment,the above indicators were more significantly improved in the observation group compared with the control group(P<0.05),and the adverse reaction incidence observation group(10.64%)was compared with the control group(6.38%),and there was no obvious difference(P>0.05).Conclusion The treatment of functional dyspepsia by siniberide combined with domperidone can enhance the efficacy,improve the quality of life of patients,improve gastric motility,and has good safety,which is worth promoting.
作者
朱平国
Zhu Pingguo(Dongshan County Hospital,Dongshan Fujian 363400,China)
出处
《医疗装备》
2022年第14期89-92,共4页
Medical Equipment
