摘要
目的:探究用翼状胬肉切除术联合角膜缘干细胞移植术(LSCT)治疗翼状胬肉的有效性及安全性。方法:选取中山市三乡医院2019年1月至2021年1月收治的50例翼状胬肉患者作为研究对象。采用随机数表法将其分为两组,其中常模组25例患者仅接受单纯的翼状胬肉切除术,研讨组25例患者接受翼状胬肉切除术联合LSCT。比较两组患者的泪液分泌试验(SIT)结果、泪膜破裂时间等各项临床指标。结果:术后6个月,研讨组患者的SIT结果高于常模组患者,其泪膜破裂时间长于常模组患者,P<0.05。研讨组患者术后的角膜上皮修复时间和住院时间均短于常模组患者,P<0.05。研讨组患者术后并发症的发生率为8.0%,常模组患者术后并发症的发生率为32.0%,组间相比,P<0.05。术后6个月内,研讨组患者病情的复发率为4.0%,常模组患者病情的复发率为24.0%,组间相比,P<0.05。结论:用翼状胬肉切除术联合LSCT治疗翼状胬肉的效果较为理想,能将胬肉有效切除,改善患者的视觉功能和眼表泪膜功能,预防其术后病情复发,且其术后并发症的发生率较低,治疗的安全性较高。
Objective:To investigate the efficacy and safety of pterygium excision combined with limbal stem cell transplantation(LSCT)in the treatment of pterygium.Methods:A total of 50 pterygium patients admitted to Sanxiang Hospital of Zhongshan city from January 2019 to January 2021 were selected as subjects.They were divided into two groups by random number table method,among which 25 patients in the normal group received pterygium excision alone,and 25 patients in the discussion group received pterygium excision combined with LSCT.The results of tear secretion test(SIT),tear film rupture time and other clinical indicators were compared between 2 groups.Results:Six months after surgery,SIT results of patients in the discussion group were higher than those in the normal group,and tear film rupture time was longer than that in the normal group,P<0.05.The postoperative corneal epithelial repair time and hospital stay in the discussion group were shorter than those in the normal group,P<0.05.The incidence of postoperative complications was 8.0%in the discussion group and 32.0%in the normal group,P<0.05.6 months after surgery,the recurrence rate of patients in the discussion group was 4.0%,the recurrence rate of patients in the normal group was 24.0%,P<0.05.Conclusion:Pterygium excision combined with LSCT is effective in the treatment of pterygium,which can effectively remove the pterygium,improve the visual function and tear film function of the patient’s eye surface,and prevent the recurrence of postoperative disease.Moreover,the incidence of postoperative complications is low,and the safety of treatment is high.
作者
林超
LIN Chao(Department of Ent,Zhongshan Sanxiang Hospital,Zhongshan 528463,Guangd ong,China)
