摘要
目的分析预防性保肝治疗在老年初治肺结核病患者中的安全性及有效性。方法选取2019年6月-2020年8月我院感染科住院的初治老年肺结核病患者90例作为研究对象,根据是否预防性使用保肝药物分为预防组43例和对照组47例。对照组予以抗结核治疗,预防组在对照组基础上联合保肝药治疗,比较两组肝功能生化指标、肝损伤发生率。结果治疗后8周,预防组ALP低于对照组,差异有统计学意义(P<0.05);治疗后2、4周,预防组肝脏生化检查异常低于对照组,差异有统计学意义(P<0.05)。结论预防性保肝治疗可改善老年初治肺结核病患者的肝功能,降低肝损伤发生率。
Objective To analyze the safety and effectiveness of preventive liver protection therapy in elderly patients with pulmonary tuberculosis.Methods A total of 90 newly diagnosed elderly patients with pulmonary tuberculosis admitted to the Infection Department of our hospital from June 2019 to August 2020 were selected as the research objects,and they were divided into the prevention group(n=43)and the control group(n=47)according to whether preventive use of liver protection drugs was carried out.The control group was treated with anti-tuberculosis treatment,and the prevention group was treated with hepatoprotective drugs on the basis of the control group.The biochemical indexes of liver function and the incidence of liver injury were compared between the two groups.Results After 8 weeks of treatment,ALP in the prevention group was lower than that in the control group,and the difference was statistically significant(P<0.05).At 2 and 4 weeks after treatment,the abnormal liver biochemical examination in the prevention group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Preventive hepatoprotective therapy can improve the liver function of elderly patients with pulmonary tuberculosis and reduce the incidence of liver injury.
作者
詹淑华
赵慧姝
陈贵儒
ZHAN Shu-hua;ZHAO Hui-shu;CHEN Gui-ru(Department of Respiratory,Aba Tibetan Autonomous Prefecture People’s Hospital,Ma'erkang 624000,Sichuan,China;Department of Infectious Disease,Aba Tibetan Autonomous Prefecture People’s Hospital,Ma'erkang 624000,Sichuan,China)
出处
《医学信息》
2022年第14期45-48,共4页
Journal of Medical Information
基金
阿坝藏族羌族自治州人民医院课题(编号:YNKY2020015)
四川省软科学研究计划项目资助(编号:2020JDR0368)。
关键词
肺结核病
预防性保肝治疗
药物性肝损伤
Pulmonary tuberculosis
Preventive hepatoprotective treatment
Drug induced liver injury
