摘要
目的探讨不同剂量氨磺必利联合盐酸哌罗匹隆对难治性精神分裂症(Treatmentresistant schizophrenia,TRS)糖脂代谢的影响。方法选取2018年6月~2020年6月本院收治的60例TRS患者作为研究对象,随机数字表分为两组各30例,对照组和观察组分别利用盐酸哌罗匹隆联合推荐剂量或小剂量的氨磺必利治疗,记录两组TRS患者疗效,糖脂代谢指标,不良反应发生率。结果两组总有效率比较未见显著差异(P>0.05);治疗后,对照组空腹血糖(fasting blood glucose,FBG),空腹胰岛素(fasting insulin,FINS),胰岛素抵抗指数(insulin resistance index,HOMA-IR),总胆固醇(total cholesterol,TC),低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C),泌乳素(Prolactin,PRL)水平均显著高于观察组(P<0.05)。对照组不良反应发生率总计为26.67%显著高于观察组的6.67%(P<0.05)。结论盐酸哌罗匹隆联合小剂量或推荐剂量的氨磺必利对TRS的疗效相当,联合小剂量氨磺必利有助稳定TRS患者糖脂代谢水平,不良反应发生率更低。
Objective To explore the effects of different doses of amisulpride combined with perospirone hydrochloride hydrate on glucose-lipid metabolism in patients with treatment-resistant schizophrenia(TRS).Methods A total of 60 TRS patients who were admitted to the hospital between June 2018 and June 2020 were enrolled as the research objects.They were divided into control group(specification-recommended dose of amisulpride combined with perospirone hydrochloride hydrate)and observation group(low-dose amisulpride combined with perospirone hydrochloride hydrate)by random number table,30 cases in each group.The curative effect,glucose-lipid metabolism indexes and incidence of adverse reactions in both groups were recorded.Results There was no significant difference in the total response rate between the two groups(P>0.05).After treatment,levels of fasting blood glucose(FBG),fasting insulin(FINS),insulin resistance index(HOMA-IR),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and prolactin(PRL)in control group were significantly higher than those in observation group(P<0.05).The total incidence of adverse reactions in control group was significantly higher than that in observation group(26.67%vs 6.67%)(P<0.05).Conclusion The curative effect of perospirone hydrochloride hydrate combined with low-dose and normal-dose amisulpride is comparable on TRS.Low-dose amisulpride is beneficial to stabilize the level of glucoselipid metabolism in TRS patients,with lower incidence of adverse reactions.
作者
栗永刚
LI Yonggang(Department of Psychiatry,Puyang Mental Health Center,Puyang 457000,China)
出处
《国际精神病学杂志》
2022年第3期433-435,443,共4页
Journal Of International Psychiatry
关键词
难治性精神分裂症
氨磺必利
哌罗匹隆
糖脂代谢
Treatment-resistant schizophrenia
Amisulpride
Piperopilone
Glucose-lipid metabolism
