摘要
肠易激综合征(Irritable Bowel Syndrome,IBS)是常见的胃肠道疾病之一,主要临床症状为腹痛、腹胀以及排便频率和性状异常。该病发病机制复杂,包括遗传因素、饮食差异、肠道菌群改变、胃肠道感染以及脑-肠轴异常等。目前缓解病症的主要方式是限制性饮食,如低“可发酵性寡糖、双糖、单糖和多元醇”(Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols, FODMAPs)饮食、低“晚期糖基化终产物”(Advanced Glycosylation End Products,AGEs)饮食、无麸质饮食以及低乳糖饮食等,能有效改善IBS患者的腹部不适症状。本文归纳了近几年国内外相关学者对于IBS的研究现状,包括IBS的病理生理学机制、低FODMAPs饮食和低AGEs饮食与IBS肠道菌群的关联、针对食物中FODMAPs成分和AGEs成分的定量检测手段以及食品加工处理技术降低食物中FODMAPs和AGEs含量的措施,以期为IBS患者提供健康有效的饮食干预策略。
Irritable bowel syndrome(IBS) is a common gastrointestinal disease. The main clinical symptoms are abdominal pain, bloating, abnormal defecation frequency and character. The pathogenesis of the disease is complex, including genetic factors, dietary differences, gut microbiota changes, gastrointestinal infection and brain-gut axis dysfunction. The main way to relieve IBS mainly focus on dietary restriction, including low fermentable oligosaccharides, disaccharides,monosaccharides and polyols(FODMAPs) diet, low advanced glycation end products(AGEs) diet, gluten-free diet and low lactose diet, which can effectively improve abdominal discomfort symptoms of IBS patients. This article summarizes the research status quo of domestic and foreign scholars for IBS in recent years, including the pathophysiological mechanism of IBS, the relationship between dietary patterns and IBS intestinal flora, quantitative detection methods for FODMAPs components and AGEs in food. Food processing technologies are also introduced to reduce the content of FODMAPs and AGEs in food, in order to provide healthy and effective dietary intervention strategies for IBS patients.
作者
柏茜茜
韩承刚
徐莹
韩劲松
曹崇江
程抒劼
BAI Xixi;HAN Chenggang;XU Ying;HAN Jingsong;CAO Chongjiang;CHENG Shujie(College of Engineering,China Pharmaceutical University,Nanjing 211198,China;National R&D Center for Chinese Herbal Medicine Processing,Nanjing 211198,China;College of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《食品工业科技》
CAS
北大核心
2022年第16期421-431,共11页
Science and Technology of Food Industry
基金
国家自然科学基金(31701595,82072017)
中央高校基本科研业务费(2632020ZD15)
大学生创新创业训练计划(202110316197)。
关键词
肠易激综合征
可发酵的寡糖双糖单糖和多元醇
晚期糖基化终产物
饮食干预
分析检测技术
irritable bowel syndrome(IBS)
fermentable oligosaccharides disaccharides monosaccharides and polyols(FODMAPs)
advanced glycosylation end products(AGEs)
dietary intervention
analysis and detection technology
