摘要
目的探讨磁共振动态增强(DCE-MRI)联合扩散加权成像(DWI)技术在食管癌患者放疗疗效评估中的应用价值。方法选取75例行放疗治疗的食管癌患者作为研究对象,于放疗前行DCE-MRI与DWI检查;于放疗后1个月时综合判断临床疗效,探讨DCE-MRI联合DWI技术在食管癌患者放疗疗效评估中的应用价值并分析其影像学特征。结果放疗后1个月,75例食管癌患者中完全缓解(CR)32例,部分缓解(PR)43例;CR患者容积转运常数(K^(trans))、容积分数(V_(e))、灌注分数(f)均低于PR患者,表现扩散系数(ADC)高于PR患者,差异均有统计学意义(P<0.05);绘制ROC曲线发现,K^(trans)、V_(e)、ADC、f用于预测食管癌患者放疗疗效的AUC分别为0.701、0.724、0.731、0.774,均有一定预测性能。结论DCE-MRI联合DWI技术在食管癌患者放疗疗效评估中的应用价值较高,临床可结合DCE-MRI与DWI图像特点评估患者放疗效果。
Objective To investigate the application value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)combined with diffusion-weighted imaging(DWI)in the evaluation of efficacy of radiotherapy in patients with esophageal cancer.Methods 75 patients with esophageal cancer who received radiotherapy were selected as the research subjects.DCE-MRI and DWI were performed before radiotherapy;the clinical efficacy was comprehensively judged one month after radiotherapy,and the application value of DCE-MRI combined with DWI technology in the evaluation of radiotherapy efficacy of esophageal cancer patients was investigated and its imaging characteristics were analyzed.Results One month after radiotherapy,among 75 patients with esophageal cancer,32 cases had complete remission(CR)and 43 cases had partial remission(PR);the volume transport constant(K^(trans)),volume fraction(V_(e))and perfusion fraction(f)of CR patients were lower than those of PR patients,and the apparent diffusion coefficient(ADC)was higher than that of PR patients,the difference was statistically significant(P<0.05);the ROC curve was drawn and found that the AUC of K^(trans),V_(e),ADC and f in predicting the efficacy of radiotherapy in patients with esophageal cancer were 0.701,0.724,0.731 and 0.774 respectively,all of them had certain predictive performance.Conclusion DCE-MRI combined with DWI is of high value in the evaluation of radiotherapy efficacy in patients with esophageal cancer,the effect of radiotherapy of patients can be evaluated by combining the image characteristics of DCE-MRI and DWI in clinic.
作者
陈美玲
刘儒鹏
冯婷婷
康小红
李宁
田新学
CHEN Meiling;LIU Rupeng;FENG Tingting(The First Affiliated Hospital of Xinxiang Medical College,Xinxiang,453100)
出处
《实用癌症杂志》
2022年第8期1296-1299,共4页
The Practical Journal of Cancer
基金
河南省医学科技攻关计划联合共建项目(编号:LHGJ20200511)。
关键词
食管癌
磁共振
动态增强
扩散加权成像
放疗
Esophageal cancer
Magnetic resonance imaging
Dynamic enhancement
Diffusion weighted imaging
Radiotherapy
