摘要
目的:探究骨转移癌伴癌性疼痛患者的中医证型及临床特征。方法:采用回顾性研究方法,搜集2021年1月1日—2021年12月31日辽宁中医药大学附属医院入院治疗的骨转移癌伴疼痛患者的一般资料、原发肿瘤情况、骨转移情况、临床指标、治疗经过,及中医四诊资料等。采用SPSS软件对中医临床症状进行分层聚类分析,结合临床实践和专业知识确定合理的中医证型,对骨转移癌伴疼痛患者的疼痛程度与疾病病程、ALP、血钙、年龄等临床资料进行统计学分析。结果:①骨转移癌伴疼痛患者的中医证型可分为阴虚内热(24.2%)、气血亏虚(22.0%)、脾肾阳虚(18.7%)、气滞血瘀(15.4%)、痰湿阻滞(11.0%)、热毒蕴结(8.8%)共6个证型。②多元Logistic回归分析结果显示,高钙血症、病理性骨折、ALP升高均是影响骨转移疼痛程度加重的独立危险因素,差异具有统计学意义(P<0.05)结论:本研究初步得出临床中骨转移癌伴疼痛患者的中医证型分布规律及疼痛程度的相关影响因素,可为临床辨证论治提供一定参考。
Objective:To explore the TCM syndrome types and clinical characteristics of patients with bone metastases and cancer pain.Methods:A retrospective study method was used to collect the general information,primary tumor,bone metastases,bone metastases,bone metastases of patients with bone metastases and pain who were admitted to the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 1,2021 to December 31,2021.Clinical indicators,treatment process,and information on the four diagnosis of traditional Chinese medicine,etc.SPSS software was used to perform hierarchical clustering analysis on TCM clinical symptoms,combined with clinical practice and professional knowledge to determine reasonable TCM syndrome types,and to analyze the pain degree and disease course,ALP,blood calcium,age and other clinical data of patients with bone metastases and pain.Statistical analysis was performed.Results:①The TCM syndrome types of patients with bone metastases and pain can be divided into Yin deficiency and internal heat (24.2%),Qi and blood deficiency (22.0%),spleen and kidney Yang deficiency (18.7%),Qi stagnation and blood stasis (15.4%),phlegm dampness block (11.0%),heat toxin accumulation (8.8%) a total of 6 syndrome types.②The results of multivariate Logistic regression analysis showed that hypercalcemia,pathological fracture,and elevated ALP were independent risk factors for the aggravation of pain in bone metastases,and the difference was statistically significant (P<0.05).Conclusion:This study preliminarily concluded that The distribution of TCM syndrome types and the related influencing factors of pain degree in patients with bone metastases and pain can provide a certain reference for clinical syndrome differentiation and treatment.
作者
刘青杨
张宁苏
邢向荣
LIU Qingyang;ZHANG Ningsu;XING Xiangrong(Liaoning University of Traditional Chinese Medicine,Liaoning Shenyang 110847,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Liaoning Shenyang 110032,China)
出处
《中医药临床杂志》
2022年第7期1310-1314,共5页
Clinical Journal of Traditional Chinese Medicine
关键词
骨转移癌
癌性疼痛
中医证型
临床特征
Bone metastasis
Cancer pain
TCM syndromes
Clinical characteristics
