摘要
目的分析结直肠癌腹腔转移引起的恶性肠梗阻应用手术治疗的临床效果。方法选取2018年1月-2021年1月在哈尔滨市第五医院进行诊治的结直肠癌腹腔转移引起的恶性肠梗阻患者52例为研究对象,根据单育分组方式将其分为参照组与观察组,每组26例。参照组患者实施造口/短路手术,观察组患者实施减瘤手术。对比和分析两组患者梗阻缓解率、并发症发生率、生存时间及炎症因子。结果观察组患者梗阻缓解率为88.46%,显著优于参照组,差异有统计学意义(χ^(2)=6.255,P=0.012);两组患者并发症发生率对比,差异无统计学意义(χ^(2)=0.102,P=0.748);观察组患者短期生存时间为(11.24±1.62)个月,显著长于参照组,差异有统计学意义(t=10.936,P<0.001);观察组患者C反应蛋白、肿瘤坏死因子-α及白介素-6指标分别为(18.92±2.54)mg/L、(24.64±2.11)ng/mL、(37.68±2.39)ng/mL,均明显优于参照组,差异有统计学意义(t=7.945、3.935、3.086,P<0.001)。结论结直肠癌腹腔转移引起的恶性肠梗阻患者选择减瘤手术进行治疗,可以改善患者短期治疗效果,降低患者炎症因子水平,对于患者短期预后效果具有积极意义。
Objective To analyze the clinical effect of surgical treatment of malignant intestinal obstruction caused by intraperitoneal metastasis of colorectal cancer,and to explore the clinical application value of different treatment methods.Methods 52 patients with malignant intestinal obstruction caused by intraperitoneal metastasis of colorectal cancer who were diagnosed and treated in Harbin Fifth Hospital from January 2018 to January 2021 were selected as the research subjects.They were divided into the reference group and the observation group according to single blind grouping method,with 26 patients in each group.The patients in the reference group were treated with stoma/short-circuit surgery,and the patients in the observation group were treated with tumor debulking surgery.The ob⁃struction relief rate,complication rate,survival time and inflammatory factors of the two groups were compared and analyzed.Results The obstructive remission rate in the observation group was 88.46%,which was significantly better than that in the reference group,and the difference was statistically significant(χ^(2)=6.255,P=0.012).There was no statistically significant difference in the incidence of complications between the two groups(χ^(2)=0.102,P=0.748).The short-term survival time of patients in the observation group was(11.24±1.62)months,which was significantly longer than that in the reference group,the difference was statistically significant(t=10.936,P<0.001).The indexes of C reactive protein,tumor necrosis factorαand interleukin-6 in the observation group were(18.92±2.54)mg/L,(24.64±2.11)ng/mL,and(37.68±2.39)ng/mL,respectively,better than the reference group,the difference was statis⁃tically significant(t=7.945,3.935,3.086,P<0.001).Conclusion Tumor reduction surgery for patients with malignant intestinal obstruction caused by intraperitoneal metastasis of colorectal cancer can improve the short-term treatment effect and reduce the level of inflammatory factors,which has positive significance for the short-term prognosis of pa⁃tients.
作者
华春波
HUA Chunbo(The First Department of General Surgery,the Fifth Hospital of Harbin,Harbin,Heilongjiang Province,150040 China)
出处
《系统医学》
2022年第12期136-139,共4页
Systems Medicine
关键词
手术
结直肠癌
恶性肠梗阻
生存时间
炎症因子
Surgery
Colorectal cancer
Malignant intestinal obstruction
Survival time
Inflammatory factors
