摘要
慢性肾脏病(CKD)是威胁人类公共健康的重大疾病之一,肾间质纤维化是各种CKD进展至终末期肾病的共同病理表现。然而肾间质纤维化的病理机制还有待阐明,临床也缺乏针对肾间质纤维化有效的治疗方法。越来越多研究表明,肾小管上皮细胞G2/M周期阻滞是肾间质纤维化发生发展中的一个重要事件。在多种肾损伤模型中,均发现肾小管上皮细胞G2/M周期阻滞和肾脏纤维化的因果关系,逆转细胞G2/M周期阻滞成为缓解肾脏纤维化的潜在靶点。此外,相关机制研究表明,包括丝裂原活化蛋白激酶(MAPK)、自噬等在内的诸多信号通路与细胞G2/M周期阻滞密切关联,共同影响肾间质纤维化的发生与进展。本文就细胞G2/M周期阻滞参与肾间质纤维化的最新研究作一综述,以期为CKD的临床诊治和新药研发提供思路。
Chronic kidney disease is one of the major diseases threatening public health. Renal interstitial fibrosis(RIF) is a common pathological manifestation of various chronic kidney diseases in the end stage. However, the pathological mechanism of RIF remains to be clarified, and there is a lack of effective treatment for that. Increasing studies have shown that G2/M cycle arrest of renal tubular epithelial cells is an important event in the occurrence and development of RIF. In a variety of renal injury models, the causal relationship between G2/M cycle arrest of renal tubular epithelial cells and renal fibrosis has been found. Reversing G2/M cycle arrest has become a potential target to alleviate renal fibrosis. In addition, studies suggested that various pathways, including MAPK and autophagy, are closely related to G2/M cycle arrest, they affect the occurrence and progress of RIF collectively. This paper reviews the latest research on the involvement of G2/M cycle arrest in RIF, in order to provide ideas for the clinical diagnosis and treatment of chronic kidney disease and the development of new drugs.
作者
柳敏娜
刘天龙(综述)
席春生(审校)
LIU Minna;LIU Tianlong;XI Chunsheng(Department of Nephrology,The 940th Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China;Department of Clinical Pharmacy,The 940th Hospital of Joint Logistic Support Force of PLA,Lanzhou 730050,China)
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
北大核心
2022年第3期261-265,共5页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
甘肃省青年科技基金(20JR5RA591)
联勤保障部队第九四〇医院专项培育项目(2021yxky026)。
