摘要
目的 观察力栓饮对冠心病患者经皮冠状动脉介入术(PCI)治疗后血清一氧化氮(NO)、血管性血友病因子(vWF)及血管生成素样蛋白2(ANGPTL2)的影响,旨在阐明力栓饮防治支架内再狭窄(ISR)的作用机制。方法 将80例接受PCI治疗的冠心病患者按随机对照原则分为2组,基础治疗组和基础治疗+力栓饮组。治疗结束后,观察2组临床疗效。于PCI术前及术后7 d,采用硝酸还原酶法检测2组患者血清NO含量,采用酶联免疫吸附法(ELISA)检测2组患者血清vWF及ANGPTL2含量。观察患者术后6个月内心血管事件及ISR的发生情况。结果 基础治疗+力栓饮组PCI术后6个月内心血管事件和ISR的发生率显著低于基础治疗组(P<0.05)。2组患者PCI术后7 d NO含量较治疗前显著升高、vWF及ANGPTL2含量较治疗前显著降低(P<0.05),且基础治疗+力栓饮组效果明显优于对照组(P<0.05)。结论 力栓饮可降低ISR的发生率,其机制可能与调控血清NO、vWF及ANGPTL2含量有关。
Objective To investigate the effects of serum NO, Von Willebrand factor( vWF) and Serum Angiopoietin Like Protein 2(ANGPTL2) in percutaneous coronary intervention(PCI) postoperative patients with coronary heart disease after treatment with Lishuan drink, so as toclarify mechanism of Lishuan drink for preventing and treating incidence of in-stent restenosis( ISR).Methods Eighty PCI Postoperative Patients with coronary heart disease patients were randomly divided intobasic treatment group and basic treatment with Lishuan drink treatment group, with 40 cases in each group. At the end of experiment, the therapeutic effects of both groups were observed. Before treatment and 7 days after treatment, serum NO levels in the two groups were detected by nitrate reductase method,serum vWF and ANGPTL2 levels were detected by enzyme-linked immunosorbent assay(ELISA). The occurrence of cardiovascular events and the incidence of in-stent restenosis within 6months after PCI were observed.Results Occurrence of cardiovascular events and incidence of ISR within 6 months after PCI in the basic treatment and Lishuan drink treatment group were significantly lower than those of the basic treatment group(P< 0. 05). NO levels in the two groups 7 day after PCI were higher than those of before PCI. vWF and ANGPTL2 levels in the two groups 7 day after PCI were lower than those of before PCI(P< 0. 05). The decrease in basic treatment and Lishuan drink treatment group was superior to that in the basic treatment group(P< 0. 05).Conclusion Lishuan drink effectively reduces the incidence of ISR, and the mechanism is probably related with the up-regulation of serum NO and the down-regulation of plasma and vWF and ANGPTL2.
作者
武丽萍
王顺明
赵亮
原军英
李杰
李慧
高健元
WU Liping;WANG Shunming;ZHAO Liang;YUAN Junying;LI Jie;LI Hui;GAO Jianyuan(Department of Cardiology,Shanxi Provincial Hospital of Traditional Chinese Medicine,Shanxi Province,Taiyuan 030012,China)
出处
《光明中医》
2022年第11期1973-1976,共4页
GUANGMING JOURNAL OF CHINESE MEDICINE
关键词
冠心病
胸痹
力栓饮
coronary heart disease
thoracic obstruction
Lishuan drink
