摘要
目的探讨非酒性精脂肪性肝病(NAFLD)发病高危因素。方法选择2018年1月至2021年6月在牡丹江医学院附属第二医院诊断治疗的NAFLD患者68例的临床资料进行回顾性分析,另选择健康体检者100名作为对照组。记录一般资料及临床资料,单因素及多因素分析NAFLD发病的高危因素。结果单因素分析结果显示,男性、年龄46~60岁、吸烟、体重指数(BMI)≥25 kg/m^(2)、合并高血压、合并糖尿病、合并冠心病、合并高尿酸血症,总胆固醇(TC)>6 mmol/l、三酰甘油(TG)≥1.7 mmol/l、低密度脂蛋白(LDL)≥3.37 mmol/l、谷丙转氨酶(ALT)>40 U/L、谷草转氨酶(AST)>40 U/L的患者NAFLD发病率更高,差异有统计学意义(P<0.05)。多因素分析结果显示,男性、46~60岁、BMI≥25 kg/m^(2)、合并糖尿病、合并高血压、TC>6 mmol/l、TG≥1.7 mmol/l、LDL≥3.37 mmol/l是NAFLD发病的高危因素(P<0.05)。结论影响NAFLD发病的因素包括性别、年龄等不可调控因素以及BMI、合并症、血脂水平等可调控因素,临床上根据患者情况,通过干预可调控因素,以达到预防治疗NAFLD的效果。
Objective To investigate the high-risk factors of incidence of nonalcoholic fatty liver disease(NAFLD).Methods The clinical data of 68 patients with NAFLD diagnosed and treated in the Second Affiliated Hospital of Mudanjiang Medical University from January 2018 to June 2021 were retrospectively analyzed,and healthy people underwent physical examination were selected as the control group(n=100).The general data and clinical data were recorded,and the high-risk factors of incidence of NAFLD were analyzed by univariate and multivariate analyses.Results The results of univariate analysis showed that the patients had a higher incidence of NAFLD who were male,aged 46-60 years,with smoking,body mass index(BMI)≥25 kg/m^(2),complicated withhypertension,diabetes,coronary heart disease,andhyperuricemia,total cholesterol(TC)>6 mmol/l,triglyceride(TG)≥1.7 mmol/L,low density lipoprotein(LDL)≥3.37 mmol/L,alanine transaminase(ALT)>40U/L,aspartate transaminase(AST)>40 U/L,with statistically significant differences(P<0.05).The results of multivariate analysis showed that high-risk factors of incidence of NAFLD were male,aged 46-60 years,BMI≥25 kg/m^(2),complicated withdiabetes and hypertension,TC>6 mmol/L,TG≥1.7 mmol/l and LDL≥3.37 mmol/L(P<0.05).Conclusion The factors that impact the incidence of NAFLD include uncontrollable factors such as gender and age,andcontrollable factors such as BMI,complications and blood lipid level.In clinic,interveningcontrollable factors according to the patient’s condition can achieve the effect of prevention and treatment of NAFLD.
作者
任春娜
张瑜
修云霞
赵德臣
杨洪亮
任宪辉
REN Chunna;ZHANG Yu;XIU Yunxia;ZHAO Dechen;YANG Hongliang;REN Xianhui(Department of Clinical Laboratory,the Second Affiliated Hospital of Mudanjiang Medical University,Heilongjiang,Mudanjiang 157001,China)
出处
《中国医药科学》
2022年第14期106-109,共4页
China Medicine And Pharmacy
基金
黑龙江省牡丹江市应用技术研究与开发计划项目(HT2020NS098)。
关键词
非酒精性脂肪性肝病
发病
高危因素
糖尿病
高血压
Nonalcoholic fatty liver disease
Incidence
High-risk factors
Diabetes
Hypertension
