摘要
目的:探讨胃复春胶囊联合四联疗法治疗幽门螺杆菌(Helicobacter pylori,Hp)阳性功能性消化不良(Functional Dyspepsia,FD)的临床效果。方法:选取2019年3月-2020年2月诊治的116例Hp阳性FD患者开展研究,根据治疗方式不同对患者分组,采用四联疗法治疗的58例患者为对照组,采用胃复春胶囊联合四联疗法方案治疗的58例患者为观察组,比较两组治疗的临床有效率、临床症状评分、Hp清除率及胃蛋白酶原I、胃蛋白酶原II的变化。结果:治疗后两组患者的各项症状均有改善,且观察组患者症状改善优于对照组;观察组患者治疗总有效率、胃蛋白酶原I、胃蛋白酶原II水平均高于对照组,治疗后Hp转阴率优于对照组,差异具有统计学意义(P<0.05);对比两组患者的不良反应发生率,差异无统计学意义(P>0.05)。结论:对Hp阳性FD患者采用胃复春胶囊联合四联疗法方案可以有效改善患者的胃肠功能,提高临床治疗的整体效果。
Objective:To investigate the clinical effect of the Weifuchun capsules(胃复春胶囊)plus quadruple therapy on Helicobacter pylori(Hp)positive functional dyspepsia.Methods:A total of 116 patients from March 2019 to February 2020 were selected and divided into the control group(58 cases)and the observation group(58 cases).The control group was given quadruple therapy;and the observation gorup was given the Weifuchun capsules more.Results:After treatment,the symptom scores in the two groups were improved in varying degrees,and the improvement degree in the observation group was greater than that in the control group.The total efficiency,pepsinogen I and pepsinogen II levels in the observation group were higher than those in the control group,the Hp negative conversion rate in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The difference of adverse reactions in the two groups were not statistically significant(P>0.05).Conclusion:Effects of the Weifuchun capsules plus quadruple therapy on Hp positive patients with functional dyspepsia is good,which can effectively improve the gastrointestinal function of patients and improve the overall effect of clinical treatment.
出处
《中医临床研究》
2022年第19期125-128,共4页
Clinical Journal Of Chinese Medicine
关键词
功能性消化不良
幽门螺杆菌
胃复春胶囊
四联疗法
Functional dyspepsia
Helicobacter pylori
The Weifuchun capsules
Quadruple therapy
