摘要
肝移植(liver transplantation,LT)手术是目前治疗各种终末期肝脏疾病的最好办法,而脓毒症依然是移植术后常见并发症之一,也是导致患者住院时间延长和死亡的主要原因。由于LT术中缺血-再灌注损伤,以及术后大剂量激素和免疫抑制剂的使用,使得术后早期准确识别脓毒症存在较大困难。近年来,关于预测LT术后新发脓毒症的生物学标志物研究日益增多,本文特针对这些研究成果进行回顾分析,以期为LT术后脓毒症的早期识别和防治提供参考。
At present,liver transplantation(LT) is the best way to treat a variety of end-stage liver diseases,while sepsis is still one of the common complications after transplantation,and it is also the main cause of prolonged hospitalization and death.Due to intraoperative ischemia-reperfusion injury,combined with the use of high-dose cortisol and immunosuppressants after operation,it is difficult to identify sepsis at the early stage after operation accurately and immediately.In recent years,research on the biomarkers for predicting new-onset sepsis after LT has been increasing.The article reviews and analyzes these research results in order to provide a guideline for the early identification and prevention of sepsis after LT.
作者
游潘
高榕悦
李文雄
黄立锋
You Pan;Gao Rong-yue;Li Wen-xiong;Huang Li-feng(Department of Surgical Intensive Care Unit,Beijing Chaoyang Hospital Affiliated to Capital Medical University,Beijing 100020,China)
出处
《中国急救医学》
CAS
CSCD
2022年第8期728-732,共5页
Chinese Journal of Critical Care Medicine
基金
北京市临床重点专科(卓越)项目(2020年度)
北京市自然科学基金面上项目(7222065)
国家自然科学基金面上项目(81372042)。
