摘要
目的探讨苯磺酸氨氯地平对高血压合并冠心病患者血压、血脂的影响。方法选取2018年3月—2020年3月广州市白云区第二人民医院收治的70例高血压合并冠心病患者,按照随机数表法分为两组,对照组35例予以阿托伐他汀钙片治疗,研究组35例加以苯磺酸氨氯地平治疗。比较两组血压、血脂水平情况。结果两组患者干预前血压、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较,差异无统计学意义(P>0.05);干预后研究组收缩压(124.19±12.57)mmHg、舒张压(84.13±8.74)mmHg均低于对照组,差异有统计学意义(t=3.187、4.149,P<0.05)。研究组HDL-C(3.34±0.21)mmol/L高于对照组,TC(4.31±0.26)mmol/L、TG(3.22±0.16)mmol/L、LDL-C(1.32±0.51)mmol/L低于对照组,差异有统计学意义(P<0.05)。结论苯磺酸氨氯地平联合阿托伐他汀钙片治疗高血压合并冠心病患者可有效降低患者血压及TC、TG、LDL-C水平。
Objective To investigate the effect of amlodipine besylate on blood pressure and blood lipids in patients with hypertension and coronary heart disease.Methods A total of 70 patients with hypertension and coronary heart disease admitted to the Second People's Hospital of Baiyun District from March 2018 to March 2020 were divided into two groups according to the random number table method.35 cases in the control group were treated with atorvastatin calcium tablets,and 35 cases in the study group were treated with amlodipine besylate.The blood pressure and blood lipid levels were compared between the two groups.Results There was no significant difference in blood pressure,TC,TG,HDL-C,LDL-C and levels before intervention between the two groups(P>0.05).After the intervention,the systolic blood pressure(124.19±12.57)mmHg and the diastolic blood pressure(84.13±8.74)mmHg in the study group were lower than those in the control group.The difference was statistically significant(t=3.187,4.149,P<0.05).The HDL-C(3.34±0.21)mmol/L in the study group was higher than that in the control group.The levels of TC(4.31±0.26)mmol/L,TG(3.22±0.16)mmol/L,and LDL-C(1.32±0.51)mmol/L were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Amlodipine besylate combined with atorvastatin calcium tablets can effectively reduce blood pressure and TC,TG,LDL-C levels in patients with hypertension complicated with coronary heart disease.
作者
邵鸿键
SHAO Hongjian(Department of Internal Medicine,the Second People's Hospital of Baiyun District,Guangzhou,Guangzhou,Guangdong Province,510450 China)
出处
《世界复合医学》
2022年第6期160-163,共4页
World Journal of Complex Medicine
关键词
高血压
冠心病
磺酸氨氯地平
血压
血脂
Hypertension
Coronary heart disease
Amlodipine sulfonate
Blood pressure
Blood lipids
