摘要
甘草泻心汤始载于汉代张仲景的《伤寒杂病论》158条和《金匮要略》第10条,临床上脾胃病的常用处方,现在也被广泛应用于自身免疫性和恶性肿瘤,2018年4月,被收录于国家中医药管理局会同国家药品监督管理局制定《古代经典名方目录(第一批)》。目前临床上主要有全方混煎与饮片单煎配颗粒两种提取制备工艺,本研究以甘草泻心汤君药的两种主要成分——甘草苷和甘草酸为评价指标,比较了混煎工艺与3个不同厂家批次的饮片配方颗粒混合两种制备工艺。结果表明在甘草苷和甘草酸提取效果方面,全方混煎优于饮片单煎配颗粒。
Gancao Xiexin Decoction was first published in Article 158 of Treatise onTreatise on Cold Pathogenic and Miscellaneous Diseases and Article 10 of Synopsis of Golden Chamber by Zhang Zhongjing in the Han Dynasty.It is a commonly used prescription for spleen and stomach diseases in clinical practice.Now it is also widely used in autoimmune and malignant tumors.In April 2018,it was included in the catalogue of ancient classical famous prescriptions(the first batch)formulated by the State Administration of traditional Chinese medicine and the State Drug Administration.At present,there are mainly two extraction and preparation processes in clinical practice,namely,the whole recipe mixed decoction and each decoction piece mixed granule.In this study,we took the content of glycyrrhizin and glycyrrhizin ammonia as the evaluation index,and the two preparation processes of the mixed decoction process and each decoction piece formula granule from three different manufacturers were compared.The results showed that the mixed decoction was better than the single decoction granules in the extraction of glycyrrhizin and glycyrrhizic acid.
作者
王志尧
王韬
张贵春
闫玉晓
姜晓
姜乐
孟鹏飞
Wang Zhiyao;Wang Tao;Zhang Guichun;Yan Yuxiao;Jiang Xiao;Jiang Le;Meng Pengfei(Henan Natural Product Biotechnology Co.,Ltd.,Henan Academy of Sciences,Zhengzhou 450002;Henan University of Chinese Medicine,Zhengzhou 450000;The First Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《广东化工》
CAS
2022年第16期48-50,共3页
Guangdong Chemical Industry
基金
河南省重点研发与推广专项(科技攻关:212102310352)
河南省科学院基本科研费项目(项目编号:220613048)
全国中医药创新骨干人才培训项目(国中医药人教函[2019]128号)
河南省中医药科学研究专项(2017JDZX037)。
关键词
甘草泻心汤
提取制备
混(合)煎
单煎
自身免疫病
Gancao Xiexin Decoction
extraction preparation
mixed frying
single fried
autoimmune disease
