摘要
目的:分析武汉地区儿童EB病毒(EBV)感染情况及流行特征。方法:回顾性分析2017-01-2021-12期间,24806例疑似EBV感染患儿外周血EBV-DNA实时荧光定量PCR检测结果,分析其不同性别、不同年龄、不同季节EBV-DNA检出情况以及相关疾病分布。结果:24806例疑似EBV感染患儿中,EBV-DNA检出阳性2825例,总阳性率为11.39%。不同性别患儿间的差异无统计学意义(P>0.05)。不同年龄组间的差异有统计学意义(P<0.05),以幼儿组为最高(14.19%),婴儿组最低(6.24%)。不同季节患儿EBV-DNA阳性率比较差异有统计学意义(P<0.01),其中秋季检出率最高(12.58%),春季检出率最低(10.51%)。不同年份患儿EBV-DNA阳性率比较差异有统计学意义(P<0.01),其中2017年检出率最高(13.45%),2020年检出率最低(8.66%)。EBV感染性疾病以传染性单核细胞增多症最多(20.85%),其次为肺炎(15.65%)、急性化脓性扁桃体炎(14.23%)、淋巴结炎(12.67%)等。结论:武汉地区1-3岁儿童最易感染EBV,且秋季多发,感染后可累及多个系统,以传染性核细胞增多症最常见。
Objective:To analyze the Epstein-Barr virus(EBV)infection and epidemic characteristics of EBV in children in Wuhan.Method:From January 2017 to December 2021,the detection results of EBV-DNA real-time quantitative PCR in peripheral blood of 24806 children with suspected EBV infection were retrospectively analyzed.The detection of EBV-DNA and the distribution of related diseases in different sexes,ages and seasons were analyzed.Results:Among 24806 children with suspected EBV infection,2825 cases were positive for EBV-DNA,and the total positive rate was 11.39%.There was no significant difference between children of different genders(P>0.05),the difference between different age groups was statistically significant(P<0.05),the highest in the infant group(14.19%)and the lowest in the infant group(6.24%).There were significant differences in the positive rate of EBV-DNA among children in different seasons(P<0.01),among which the detection rate was the highest in autumn(12.58%)and the lowest in spring(10.51%).There was a statistically significant difference in the positive rate of EBV-DNA among children in different years(P<0.01),with the highest detection rate in 2017(13.45%)and the lowest in 2020(8.66%).Infectious mononucleosis was the most common EBV infectious disease(20.85%),followed by pneumonia(15.65%),acute suppurative tonsillitis(14.23%),lymphadenitis(12.67%).Conclusion:Children aged 1-3 years in Wuhan are most susceptible to EBV infection,and it is more common in autumn.After infection,multiple systems can be involved,and infectious mononucleosis is the most common.
作者
李革
余怡如
陈放
黄永建
LI Ge;YU Yi-ru;CHEN Fang;HUANG Yong-jian(Department of Pediatrics,Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science&Technology,Wuhan 430030,China)
出处
《微循环学杂志》
2022年第3期48-51,共4页
Chinese Journal of Microcirculation
关键词
儿童
EB病毒
感染
流行季节
Children
EB virus
Infected
Popular season
