摘要
目的:探究通关藤注射液与顺铂联合治疗膀胱癌的临床效果及可能的作用机制。方法:按照随机数字表法将2017年1月至2021年3月于我院接受治疗的90例膀胱癌患者分为对照组和观察组,每组各45例。对照组采用顺铂进行化疗,观察组采用通关藤注射液与顺铂联合治疗,两组均持续治疗2个疗程。比较两组患者治疗前后癌细胞增殖和侵袭相关指标、免疫细胞水平及两组的临床疗效。结果:观察组治疗有效率高于对照组(P<0.05)。与对照组相比,观察组患者治疗后癌细胞增殖相关指标血清细胞周期蛋白D1(Cyclin D1)、zeste基因增强子人类同源物2(EZH2)的mRNA相对表达量减小更明显(P<0.05);血清成纤维细胞生长因子21(FGF21)水平升高更明显,组织因子(TF)和血管内皮生长因子(VEGF)水平下降均更明显(P<0.05);外周血CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、自然杀伤细胞(NK)水平升高均更明显(P<0.05),CD8^(+)水平下降更明显(P<0.05)。结论:通关藤注射液与顺铂联合治疗能有效提高膀胱癌患者临床疗效,可能与抑制癌细胞增殖和侵袭相关因子的表达以及调节T淋巴细胞亚群平衡等有关。
Objective:To explore the clinical effect and possible mechanism of tongguanteng injection combined with cisplatin in the treatment of bladder cancer.Methods:According to the random number table method,90 patients with bladder cancer who were treated in our hospital from January 2017 to March 2021 were divided into the control group and the observation group,with 45 cases in each group.The control group was treated with cisplatin,while the observation group was treated with tongguanteng injection combined with cisplatin.Both groups continued to be treated for 2 courses.The indexes related to the proliferation and invasion of cancer cells,the level of immune cells before and after the treatment and the clinical efficacy of the two groups were compared.Results:The treatment effective rate of the observation group was higher than that of the control group(P<0.05).Compared with the control group,the mRNA relative expression of serum cyclin D1 and enhancer of zeste homologue 2(EZH2)of patients in the observation group decreased more obviously after the treatment(P<0.05).The serum level of fibroblast growth factor 21(FGF21)increased more obviously,and the levels of tissue factor(TF)and vascular endothelial growth factor(VEGF)decreased more obviously in the observation group after the treatment(P<0.05).The levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and natural killer cells(NK)in peripheral blood increased more obviously(P<0.05),and the level of CD8^(+)decreased more obviously in the observation group after the treatment(P<0.05).Conclusion:Tongguanteng injection combined with cisplatin can effectively improve the clinical efficacy of bladder cancer patients,which may be related to inhibiting the expression of factors related to cancer cell proliferation and invasion and regulating the balance of T lymphocyte subsets.
作者
赵新
冯小燕
张妮
荆晶
ZHAO Xin;FENG Xiaoyan;ZHANG Ni;JING Jing(The Affiliated Hospital of Northwest University/Xi′an No.3 Hospital,Shaanxi Xi′an 710018,China;Xi′an Hospital of Traditional Chinese Medicine,Shaanxi Xi′an 710021,China;Xijing Hospital,Shaanxi Xi′an 710032,China)
出处
《中国医药导刊》
2022年第6期588-592,共5页
Chinese Journal of Medicinal Guide
关键词
膀胱癌
顺铂
通关藤注射液
联合治疗
疗效
作用机制
Bladder cancer
Cisplatin
Tongguanteng injection
Combined therapy
Efficacy
Mechanism of action
