摘要
目的探讨慢性乙型肝炎(CHB)患者血清25-羟基维生素D_(3)[25(OH)D_(3)]水平与抗病毒疗效及肝脏炎症分期的关系。方法选取120例CHB患者,根据治疗方式分为辅助治疗组(65例)、常规治疗组(55例)。采用Scheuer评分系统判定肝脏炎症分期,其中G1期12例、G2期54例、G3期39例、G4期15例。采用Pearson相关分析或Spearman相关分析评估各项指标之间的相关性。结果常规治疗组与辅助治疗组治疗12周乙型肝炎病毒(HBV)DNA和乙型肝炎e抗原(HBeAg)的转阴率差异均无统计学意义(P>0.05),治疗24周HBV DNA和HBeAg的转阴率差异均有统计学意义(P<0.05)。辅助治疗组与常规治疗组治疗前血清25(OH)D_(3)水平差异无统计学意义(P>0.05),治疗24周后2个组血清25(OH)D_(3)水平均显著高于治疗前(P<0.01),且辅助治疗组高于常规治疗组(P<0.001)。血清γ-干扰素(INF-γ)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平随CHB患者肝脏炎症分期的升高而升高(P<0.05),血清25(OH)D_(3)水平随肝脏炎症分期的升高而降低(P<0.05)。Spearman相关分析结果显示,25(OH)D_(3)水平与肝脏炎症分期呈负相关(r=-0.715,P<0.001);Pearson相关分析结果显示,25(OH)D_(3)与IL-6、TNF-α均呈负相关(r值分别为-0.262、-0.216,P<0.05),与INF-γ无相关性(r=-0.053,P>0.05)。结论CHB患者血清25(OH)D_(3)水平与肝脏炎症分期、抗病毒疗效有关。
Objective To investigate the relationship between serum 25-hydroxyvitamin D_(3)[25(OH)D_(3)]levels and the efficacy of antiviral therapy and liver inflammatory stage in patients with chronic hepatitis B(CHB).Methods Totally,120 patients with CHB were enrolled and classified into auxiliary group(65 cases)and conventional group(55 cases).They were classified into stage G1 group(12 cases),stage G2 group(54 cases),stage G3 group(39 cases)and stage G4 group(15 cases)according to the Scheuer scores of liver inflammatory stages.Pearson or Spearman correlation analysis was used to assess the correlation between the indicators.Results The differences in the rates of hepatitis B virus(HBV)DNA and hepatitis B e antigen(HBeAg)conversion between conventional and auxiliary groups at 12 weeks of treatment had no statistical significance(P>0.05),and the differences in the rates of HBV DNA and HBeAg conversion at 24 weeks of treatment were statistically significant(P<0.05).The difference in serum 25(OH)D_(3) levels between auxiliary and conventional groups before treatment was not statistically significant(P>0.05).After 24 weeks of treatment,serum 25(OH)D_(3) levels in the 2 groups were higher than those before treatment(P<0.01),and those of auxiliary group were higher than those in conventional group(P<0.001).Serum interferon-gamma(INF-γ),interleukin-6(IL-6)and tumor necrosis factor-alpha(TNF-α)levels were increased with the increasing liver inflammatory stages in CHB patients(P<0.05),and serum 25(OH)D_(3) levels were decreased with the increasing liver inflammatory stages(P<0.05).Spearman correlation analysis showed that 25(OH)D_(3) was negatively correlated with liver inflammatory stage(r=-0.715,P<0.001).Pearson correlation analysis showed that 25(OH)D_(3) was negatively correlated with IL-6 and TNF-α(r=-0.262 and-0.216,P<0.05)and had no correlation with INF-γ(r=-0.053,P>0.05).Conclusions Serum 25(OH)D_(3) levels in CHB patients are related with liver inflammatory stage and antiviral therapy efficacy.
作者
刘洋
耿坤静
栗红江
石昊曦
陈思思
LIU Yang;GENG Kunjing;LI Hongjiang;SHI Haoxi;CHEN Sisi(Department of Clinical Laboratory,the Baoding People's Hospital,Baoding 071000,Hebei,China;Department of Gastroenterology,the Baoding People's Hospital,Baoding 071000,Hebei,China)
出处
《检验医学》
CAS
2022年第7期628-631,共4页
Laboratory Medicine
基金
保定市科技计划项目(2041ZF149)
