摘要
缺血再灌注损伤(ischemia reperfusion injury,IRI)作为临床常见并发症,可引起严重不良预后。然而,其损伤机制尚未完全阐明,临床治疗效果仍不理想。细胞焦亡作为一种可导致炎症反应的程序性细胞死亡,与器官IRI息息相关。文章简述了细胞焦亡的分子特征、机制,对细胞焦亡与心、脑、肾等器官IRI的关系和细胞焦亡与凋亡在IRI中的相互作用进行综述,并总结了目前针对细胞焦亡的治疗方式,旨在为器官IRI的防治提供理论依据,以期更好地指导临床工作。
Ischemia reperfusion injury(IRI),a common clinical complication,can cause severe adverse prognosis.However,the mechanism of injury has not been fully elucidated,and the clinical therapeutic effect is still not ideal.As a programmed cell death that can lead to inflammatory response,pyroptosis is closely related to organ IRI.This article briefly describes the molecular characteristics and mechanisms of pyroptosis,reviews the relationship between pyroptosis and IRI in organs such as heart,brain and kidney.Also,we de⁃scribes the interaction between pyroptosis and apoptosis in IRI,as well as summarizing the current treatment methods for pyroptosis.The target of this article is aim to provide the theoretical basis for the prevention and treatment of organ IRI,so as to better guide clinical work.
作者
录亚鹏
郝伟
钟海莲
刘洋
王迎斌
Lu Yapeng;Hao Wei;Zhong Hailian;Liu Yang;Wang Yingbin(Department of Anesthesiology,the Second Hospital of Lanzhou University,Lanzhou 730030,China)
出处
《国际麻醉学与复苏杂志》
CAS
2022年第7期776-780,共5页
International Journal of Anesthesiology and Resuscitation
关键词
细胞焦亡
缺血再灌注损伤
器官保护
Pyroptosis
Ischemia reperfusion injury
Organ protection
