摘要
目的:探讨不同放疗剂量应用于晚期肺癌患者的近远期疗效。方法:选取中国人民武装警察部队河南省总队医院2018年9月至2021年1月期间收治的81例晚期肺癌患者,按照随机数字表法分为对照组40例和观察组41例。对照组予以高剂量放疗,观察组予以低剂量放疗,观察两组患者的近远期疗效、肿瘤标志物、免疫功能及不良反应发生情况。结果:观察组总有效率78.05%,对照组总有效率70.00%,两组比较差异无统计学意义(P>0.05);两组复发率、死亡率比较,差异无统计学意义(P>0.05);两组放疗后糖类抗原125(CA125)、癌胚抗原(CEA)以及细胞角蛋白19片段抗原21–1(CYFRA21–1)水平均低于放疗前,两组比较差异无统计学意义(P>0.05);两组放疗后CD4^(+)、CD3^(+)水平均低于放疗前,而观察组高于对照组,CD8^(+)水平均高于治疗前,而观察组低于对照组,差异具有统计学意义(P<0.05);观察组不良反应发生率7.32%,低于对照组25.00%,差异具有统计学意义(P<0.05)。结论:低剂量放疗应用于晚期肺癌患者能够降低肿瘤标志物含量,提高免疫功能,降低不良反应发生率,且与高剂量放疗的近远期疗效相近。
Objective To investigate the short-term and long-term effects of different radiotherapy doses in patients with advanced lung cancer.Methods A total of 81 patients with advanced lung cancer admitted to Henan Provincial Armed Police Corps Hospital from September 2018 to January 2021 were selected and divided into a control group with 40 cases and an observation group,with 41 cases according to the random number table method.The control group was given high-dose radiotherapy,the observation group was given low-dose radiotherapy,and the short-term and long-term efficacy,tumor markers,immune function and the occurrence of adverse reactions were observed in the two groups.Results The total effective rate was 78.05%in the observation group and 70.00%in the control group,and there was no significant difference between the two groups(P>0.05).There was no significant difference in recurrence rate and mortality between the two groups(P>0.05).The levels of carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA)and cytokeratin 19 fragment antigen 21-1(CYFRA21-1)in the two groups after radiotherapy were lower than those before radiotherapy,and there was no statistical significance between the two groups(P>0.05).The levels of CD4^(+)and CD3^(+)in the two groups after radiotherapy were lower than before treatment,while the levels of the observation group were higher than those of the control group,and the level of CD8^(+)was higher than before treatment,while the level of CD8^(+)of the observation group was lower than the that of the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 7.32%,lower than 25.00%in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of low-dose radiotherapy to patients with advanced lung cancer can reduce the content of tumor markers,improve immune function,and reduce the incidence of adverse reactions,and the short-term and long-term efficacy of low-dose radiotherapy is comparable to that of high-dose radiotherapy.
作者
谷美林
罗俊波
豆华丽
GU Mei-lin;LUO Jun-bo;DOU Hua-li(Chinese People's Armed Police General Hospital,Henan Zhengzhou 450000)
出处
《深圳中西医结合杂志》
2022年第10期13-16,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
晚期肺癌
调强放射治疗
不同放疗剂量
近远期疗效
Advanced lung cancer
Intensity modulated radiotherapy
Different radiation doses
Short-term and long-term efficacy
