摘要
目的通过检测肺腺癌组织中转录因子Oct4的阳性表达程度,研究Oct4在肺腺癌中的临床意义。方法以2019年1月-2021年1月在我院诊断为肺腺癌且手术治疗的120例患者为研究对象,在手术过程中分别收集患者肺癌及相应的癌旁组织标本,制作病理组织切片,免疫组化法检测Oct4的表达水平。结果在肺腺癌的癌旁组织中,转录因子Oct4几乎没有阳性表达;在肺腺癌组织中,Oct4的阳性表达率为73.3%;在伴有淋巴结转移的肺腺癌组织中,Oct4的阳性表达率为79.5%。Oct4阳性表达率在低分化肺腺癌组织中是80%,在中分化肺腺癌组织中是71.4%,在高分化肺腺癌组织中是68.7%。结论Oct4在肺腺癌组织中呈阳性表达,且在不同分化程度的肺腺癌组织中表达水平有差异,组织分化越低,Oct4的阳性表达率越高。当合并淋巴结转移时,Oct4阳性表达率也相对更高。
Objective To study the clinical significance of octamer binding transcription factor 4(Oct4)in lung adenocarcinoma by detecting the positive expression of Oct4 in lung adenocarcinoma.Methods A total of 120 patients who were diagnosed with lung adenocarcinoma and underwent surgical treatment in our hospital from January 2019 to January 2021 were selected as the research objects.During the operation,lung cancer and corresponding adjacent tissue samples were collected,and pathological tissue sections were made.The expression level of Oct4 was detected by immunohistochemistry.Results In the adjacent tissue of lung adenocarcinoma,the transcription factor Oct4 was almost not positively expressed;in lung adenocarcinoma tissues,the positive expression rate of Oct4 was 73.3%;in lung adenocarcinoma with lymph node metastasis,the positive expression rate of Oct4 was 79.5%.The positive expression rate of Oct4 was 80%in poorly differentiated lung adenocarcinoma tissues,71.4%in moderately differentiated lung adenocarcinoma tissues,and 68.7%in well-differentiated lung adenocarcinoma tissues.Conclusion Oct4 is positively expressed in lung adenocarcinoma tissues,and the expression levels are different in lung adenocarcinoma tissues with different degrees of differentiation.The lower the tissue differentiation,the higher the positive expression rate of Oct4.When combined with lymph node metastasis,the positive expression rate of Oct4 is also relatively higher.
作者
常晶
王蓓
张敬剑
莫慧敏
倪云峰
郏琴
CHANG Jing;WANG Bei;ZHANG Jing-Jian;MO Hui-min;NI Yun-feng;JIA Qin(Department of Respiratory and Critical Care Medicine,Shidong hospital of Shanghai Yangpu District,Shanghai 200438,China)
出处
《临床肺科杂志》
2022年第9期1382-1385,共4页
Journal of Clinical Pulmonary Medicine
关键词
肺癌
腺癌
OCT4
免疫组织化学
Lung cancer
Adenocarcinoma
Oct4
Immunohistochemistry
