摘要
目的研究对冠心病心律不齐患者实施美托洛尔联合胺碘酮治疗的效果。方法76例冠心病心律不齐患者,按照入院的先后顺序分为对照组和实验组,每组38例。对照组患者采用盐酸胺碘酮注射液与盐酸胺碘酮片进行序贯治疗,实验组患者在对照组基础上采用琥珀酸美托洛尔缓释片进行治疗。比较两组患者治疗前后心率(HR)、血压[收缩压(SBP)和舒张压(DBP)]水平,治疗效果,治疗过程中不良反应发生情况。结果治疗后,两组患者的HR、SBP以及DBP水平均低于治疗前,且实验组患者的HR(73.15±3.68)次/min、SBP(111.23±5.16)mm Hg(1 mm Hg=0.133 kPa)以及DBP(71.36±2.98)mm Hg均低于对照组的(96.84±3.87)次/min、(134.69±8.15)mm Hg、(89.06±5.02)mm Hg,差异均有统计学意义(P<0.05)。实验组患者治疗总有效率为94.74%,显著高于对照组的76.32%,差异具有统计学意义(P<0.05)。实验组患者在治疗过程中不良反应发生率为10.53%,显著低于对照组的31.58%,差异具有统计学意义(P<0.05)。结论美托洛尔联合胺碘酮在冠心病心律不齐患者中的治疗效果较好,不良反应少,值得临床推广应用。
Objective To study the therapeutic effect of metoprolol combined with amiodarone in the treatment of coronary heart disease with arrhythmia.Methods A total of 76 patients with coronary heart disease and arrhythmia were divided into control group and experimental group according to the order of admission,with 38 cases in each group.Patients in the control group were treated with amiodarone hydrochloride injection and amiodarone hydrochloride tablets sequentially,and patients in the experimental group were treated with metoprolol succinate sustained-release tablets on the basis of the control group.The levels of heart rate(HR),blood pressure[systolic blood pressure(SBP)and diastolic blood pressure(DBP)]before and after treatment,therapeutic effect,and occurrence of adverse reactions during treatment were compared between the two groups.Results After treatment,the HR,SBP and DBP levels of the two groups were lower than those of this group before treatment;the HR(73.15±3.68)times/min,SBP(111.23±5.16)mm Hg(1 mm Hg=0.133 kPa)and DBP(71.36±2.98)mm Hg of the experimental group were lower than(96.84±3.87)times/min,(134.69±8.15)mm Hg and(89.06±5.02)mm Hg of the control group,and the differences were statistically significant(P<0.05).The total effective rate 94.7%in the experimental group was significantly higher than 76.32%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 10.53%in the experimental group was significantly lower than 31.58%in the control group,and the difference was statistically significant(P<0.05).Conclusion Metoprolol combined with amiodarone has a better therapeutic effect in patients with coronary heart disease and arrhythmia,and the adverse reactions is less,which is worthy of clinical promotion and application.
作者
刘晓晨
LIU Xiao-chen(Panjin Central Hospital,Panjin 124010,China)
出处
《中国现代药物应用》
2022年第14期119-121,共3页
Chinese Journal of Modern Drug Application
关键词
美托洛尔
胺碘酮
冠心病
心律不齐
Metoprolol
Amiodarone
Coronary heart disease
Arrhythmia
