摘要
目的 探讨术前血清前白蛋白(preALB)水平与不可切除肝癌患者行TACE术预后的关系.方法 回顾性分析2007年1月至2018年12月在3家医疗机构行TACE治疗的不可切除肝癌患者768例.以术前血清前白蛋白170 mg/L为临界值,将患者分为低水平组和正常水平组.采用Cox回归模型分析影响生存的预后因素.采用Kaplan-Meier法绘制生存曲线,采用log-rank检验进行生存分析,比较两组之间的总体生存期(OS)和无进展生存期(PFS).结果 768例肝癌患者中,正常组267例,低水平组501例.术前血清前白蛋白是OS(HR:1.490,95%CI:1.231~1.805,P<0.01)和PFS(HR:1.394,95%CI:1.174~1.656,P<0.01)的独立预测因子.正常组前血清白蛋白的OS和PFS显著高于低水平组(21.6个月比16.4个月,P<0.01;13.5个月比7.6个月,P<0.01).结论 术前血清前白蛋白水平可以预测不可切除肝癌患者TACE术后的预后.
Objective To investigate the correlation between preoperative serum prealbumin(preALB) level and the prognosis in patients with inoperable hepatocellular carcinoma(HCC) after receiving transcatheter arterial chemoembolization(TACE). Methods The clinical data of patients with inoperable HCC,who received initial TACE treatment in three medical institutions between January 2007 and December 2018,were retrospective analyzed. Taking preoperative serum preALB level of 170 mg/L as the cut-off value, the patients were divided into low preALB level group(low-level group)and normal preALB level group(normallevel group). Cox regression model was used to analyze the prognostic factors affecting survival. Kaplan-Meier method was adopted to draw survival curves and the log-rank test was used to make survival analysis. The overall survival(OS) and progression-free survival(PFS) were compared between the two groups. Results A total of 782 HCC patients were enrolled in this study, including 270 patients in normal-level group and 512patients in the low-level group. The results showed that preoperative preALB level was an independent predictor for OS(HR:1.490, 95%CI:1.231-1.805, P<0.01) as well as for PFS(HR:1.394, 95%CI:1.174-1.656,P<0.01). The OS and PFS in the normal-level group were significantly higher than those in the low-level group(21.6 months versus 16.4 months,P <0.01 and 13.5 months versus 7.6 months,P <0.01, respectively).Conclusion Preoperative preALB level can be used to predict the prognosis in patients with inoperable HCC after receiving TACE treatment.
作者
侯忠衡
张磊
王祁
王凯
朱晓黎
倪才方
HOU Zhongheng;ZHANG Lei;WANG Qi;WANG Kai;ZHU Xiaoli;NI Caifang(Department of Interventional Radiology,First Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province 215006,China)
出处
《介入放射学杂志》
CSCD
北大核心
2022年第6期587-592,共6页
Journal of Interventional Radiology
基金
江苏省“科教强卫工程”医学创新团队项目(CXTDB2017006)。
关键词
肝细胞癌
经动脉化疗栓塞术
前白蛋白
白蛋白
预后
hepatocellular carcinoma
transcatheter arterial chemoembolization
prealbumin
albumin
prognosis
