摘要
目的 探讨慢性肾脏病维持性血液透析患者血清sKlotho蛋白变化及意义。方法 选取153例慢性肾脏病维持性血液透析患者为研究对象。检测血清sKlotho蛋白,根据sKlotho蛋白分布范围中位数分为低水平组和高水平组。比较两组随访期间新发非致死性心血管疾病(CVD)发生率、全因死亡率,以及sKlotho蛋白对全因死亡的影响。结果 低水平组高血压发生率大于高水平组(P<0.05)。随访48个月,发生203例次新发非致死性CVD,低水平组脑血管意外、外周动脉栓塞发生率大于高水平组(P<0.05)。共死亡52例,40例死于CVD,低水平组全因死亡率、CVD病死率大于高水平组(P<0.05)。sKlotho是患者全因死亡的独立影响因素(P<0.05)。结论 慢性肾脏病维持性血液透析患者血清sKlotho蛋白与患者新发非致死性CVD和全因死亡率相关。
Objective To investigate the changes and significance of serum sklotho protein in maintenance hemodialysis patients with chronic kidney disease.Methods 153 patients with chronic kidney disease on maintenance hemodialysis were selected as the research objects.Serum sklotho protein was detected and divided into low-level group and high-level group,according to the median distribution range of sklotho protein.The incidence of new non-fatal cardiovascular disease(CVD),all-cause mortality and the effect of sklotho protein on all-cause mortality were compared between the two groups during the follow-up period.Results The incidence of hypertension in low-level group was higher than that in high-level group(P<0.05).After 48 months of follow-up,203 cases of new non-fatal CVD occurred.The incidence of cerebrovascular accident and peripheral arterial embolism in the low-level group was higher than that in the high-level group(P<0.05).A total of 52 cases died,40 cases died of CVD.The all-cause mortality and CVD mortality of the low-level group were higher than those of the high level group(P<0.05).Sklotho was an independent factor of all-cause death(P<0.05).Conclusion Serum sklotho protein is associated with new non-fatal CVD and all-cause mortality in maintenance hemodialysis patients with chronic kidney disease.
作者
卫向丽
Wei Xiangli(The second People's Hospital of Mengjin County,Luoyang,Henan 471100)
出处
《辽宁医学杂志》
2022年第4期96-98,共3页
Medical Journal of Liaoning
