摘要
This study aimed to describe the situation of iodine supplementation in pregnant women,and to explore the effects of such supplementation measures on iodine nutrition and thyroid function.Pregnant women in seven provinces were selected by multi-stage sampling.Basic information was collected and a food frequency questionnaire was administered.Salt iodine,urinary iodine,and thyroid function were determined.Subjects were divided into five groups based on iodine supplementation.For pregnant women,the median urinary iodine concentration(MUIC)in seven provinces was 164.3μg/L,and thyroid nodules(15.75%)were a common thyroid disease.Gestation,iodine supplementation,etc.impacted iodine nutrition and thyroid function.Compared with other groups,simultaneous iodine supplementation with iodized salt,iodine-rich foods,and iodine preparations(the ISFP group)was the most effective approach for improving iodine nutrition;supplementation via iodine-rich foods only showed the lowest prevalence of TPOAb-positive(5.48%)and TgAb-positive(1.37%)diseases.In addition,pregnant women with MUIC in the 150–249μg/L range showed higher rates of TPOAb-positive(13.78%)disease and sub-hypothyroidism(5.38%)compared to those with MUIC in the 100–149μg/L range;however,goiter showed the opposite trend.Our results indicate that iodine supplementation needs vary from person to person.
基金
supported by National nature science fund, 81773370
The 2019 China Hygiene and Health Standard Project, 20190502
