摘要
目的:探讨与分析补肾调经汤联合B超对卵巢储备功能不良(DOR)患者辅助生殖技术中胚胎质量的影响。方法:选择2018年8月到2021年1月在本院就诊的58例卵巢储备功能减退不孕患者作为研究对象,根据1:1随机分配原则把患者分为汤药组与对照组各29例。对照组给予戊酸雌二醇片联合地屈孕酮片治疗,汤药组在对照组治疗的基础上给予补肾调经汤口服治疗,治疗观察3个月经周期。结果:治疗后汤药组的总有效率96.6%,高于对照组的75.9%(P<0.05),所有患者在治疗期间无出现不良反应情况。两组治疗后的血清促黄体生成素(LH)、雌二醇(E2)含量低于治疗前,汤药组低于对照组(P<0.05)。两组治疗后的卵巢动脉收缩期峰值流速(PSV)与卵巢动脉舒张末期流速(EDV)都高于治疗前,汤药组高于对照组(P<0.05)。两组治疗后的窦状卵泡数高于治疗前,汤药组高于对照组(P<0.05)。所有患者治疗后随访1年,汤药组的1年妊娠率为72.4%,高于对照组的27.6%(P<0.05)。结论:补肾调经汤在卵巢储备功能不良患者的应用能促进提高B超窦状卵泡数,提高卵巢动脉的血流速度,有利于性激素分泌正常,可提高胚胎质量,发挥整体治疗效果,有利于促进患者妊娠。
Objective:To explore and analysis the effects of Bushen Tiaojing Decoction combined with B-ultrasound on embryo quality in assisted reproductive technology in patients with decreased ovarian reserve(DOR).Methods:From August 2018 to January2021,A total of 58 cases of infertile patients with reduced ovarian reserve who were treated in our hospital were selected as the research subjects,and the patients were divided into the decoction group and the matched group with 29 patients in each group accorded to the 1:1random allocation principle.The matched group were given estradiol valerate tablets combined with dydrogesterone tablets for treatment,the decoction group were given the oral treatment of Bushen Tiaojing Decoction on the basis of the treatment of the matched group,and the treatment were observed for 3 menstrual cycles.Results:After treatment,the total effective rates of the decoction group were 96.6 %,which were higher than that of the matched group of 75.9 %(P<0.05).All patients had no adverse reactions during the treatment period.The levels of serum luteinizing hormone(LH) and estradiol(E2) in the two groups after treatment were lower than those before treatment,and those in the decoction group were lower than those in the matched group(P<0.05).The peak systolic velocity(PSV) and end-diastolic flow velocity(EDV) of ovarian artery in both groups after treatment were higher than those before treatment,and the decoction group were higher than the matched group(P<0.05).The number of antral follicles in the two groups after treatment were higher than that before treatment,and the decoction group were higher than that in the matched group(P<0.05).All patients were followed up for 1year after treatment,the 1-year pregnancy rate in the decoction group were 72.4 %,which were higher than that in the matched group(27.6 %)(P<0.05).Conclusion:The application of Bushen Tiaojing decoction in patients with poor ovarian reserve function can promote the number of sinus follicles of B-ultrasound,improve the blood flow rate of ovarian artery,facilitate the normal secretion of sex hormones,improve the quality of embryos,exert the overall therapeutic effect,and facilitate the pregnancy of patients.
作者
李娜
张祁红
肖风娟
王瑛
胡梦迪
LI Na;ZHANG Qi-hong;XIAO Feng-juan;WANG Ying;HU Meng-di(Department of Gynecology,Shaanxi Academy of Tradional Chinese Medicine(Shaanxi Hospital of Traditional Chinese Medicine),Xi'an,Shaanixi,710003,China;Department of B ultrasonic,Shaanxi Academy of Tradional Chinese Medicine(Shaanxi Hospital of Traditional Chinese Medicine),Xi'an,Shaanixi,710003,China)
出处
《现代生物医学进展》
CAS
2022年第13期2550-2554,共5页
Progress in Modern Biomedicine
基金
陕西省自然科学基础研究计划项目(2020JM-669)。
关键词
补肾调经汤
卵巢储备功能不良
B超
Bushen Tiaojing Decoction
Decreased ovarian reserve
B-ultrasound
