摘要
目的比较倾向性评分匹配后的慢性肾脏病(chronic kidney disease,CKD)45期未透析患者同期辅助中药保留灌肠治疗与常规治疗的短期临床疗效。方法回顾性分析2016年2月—2021年9月在芜湖市第一人民医院接受住院治疗的确诊CKD 45期(未接受透析治疗)患者的临床资料,采用倾向性评分匹配后,最终纳入98例患者,观察组和对照组各49例。观察组在常规对症治疗的同时接受中药保留灌肠辅助治疗,每日1次,疗程持续(10.2±3.64)d。比较分析两组患者治疗前后各项实验室指标、有效率及生命质量。结果治疗前,两组患者RBC、WBC、PLT、Hb、ALB、SCr、BUN、UA及eGFR水平差异无统计学意义(P>0.05);治疗后,两组患者血清SCr、BUN及UA均有改善(P<0.05),观察组患者血清SCr、BUN及UA等指标改善均优于对照组,差异有统计学意义(P<0.05);且治疗后观察组患者总体有效率(93.33%)高于对照组(71.67%),差异有统计学意义(P<0.05)。治疗前,两组患者健康相关生命质量评分各维度指标均无统计学差异(P>0.05);治疗后,观察组患者健康相关生命质量评分各维度指标均高于对照组,差异有统计学意义(P<0.05)。治疗期间观察组患者未报告灌肠相关并发症。结论中药保留灌肠联合西医常规治疗手段用于CKD 45期患者透析前的过渡期治疗,操作安全,可改善患者血清Scr、BUN及UA等实验室检测指标和生命质量,提高患者短期疗效,作为辅助治疗手段具有一定的临床实用价值。
Objective To investigate the short-term clinical effects of adjuvant Chinese medicine retention enema treatment for chronic kidney disease(CKD)stage 45 patients without dialysis using propensity score matching.Methods Clinical data of patients with CKD stage 45 treated in Wuhu First People s Hospital from February 2016 to September 2021 were retrospectively analyzed.The propensity score matching method was used and total 98 patients were finally enrolled:49 in control group who received conventional treatment and 49 in study group who received Chinese herbal medicine retention enema daily for average 10.2±3.64 days in addition to conventional treatment.The laboratory indicators,effective rate and quality of life of the two groups before and after treatment were compared.Results Before treatment,there were no significant differences in the levels of RBC,WBC,PLT,Hb,ALB,SCr,BUN,UA and eGFR between the two groups(P>0.05).The serum Scr,BUN and UA levels were significantly decreased in both groups after treatment(P<0.05),while the improvement of study group was more marked than that of the control group(P<0.05).The overall effective rate of the study group was higher than that of the control group(93.33%vs 71.67%,P<0.05).There was no statistical difference in each dimension of the health-related quality of life score between the two groups before treatment(P>0.05);after treatment,the health-related quality of life scores in the study group were higher than those in the control group(P<0.05).No enema-related complications were reported in the study group during treatment.Conclusion Traditional Chinese medicine retention enema combined with conventional treatments is safe and effective for patients with CKD stage 45 before dialysis.
作者
唐雪敏
曹鹏
刘晓亮
陈欣
陈宇
谢金波
TANG Xuemin;CAO Peng;LIU Xiaoliang;CHEN Xin;CHEN Yu;XIE Jinbo(Department of Nephrology,Wuhu First Peoples Hospital,Wuhu 241000,Anhui Province,China;Department of Traditional Chinese Medicine,Wuhu First Peoples Hospital,Wuhu 241000,Anhui Province,China;School of Medicine,Tongji University,Shanghai 200092,China)
出处
《同济大学学报（医学版）》
CAS
2022年第4期545-551,共7页
Journal of Tongji University(Medical Science)
基金
国家自然科学基金面上项目(32070646)
芜湖市第一人民医院院级科研项目(2020WYY044N)。
关键词
中药保留灌肠
慢性肾脏病
非透析治疗
Chinese herbal medicine retention enema
chronic kidney disease
non-dialysis therapy
