摘要
Astrocytes,the most abundant cells in the central nervous system(CNS),have a variety of functions such as providing nutrients for neurons,facilitating the formation and functioning of synapses,pruning synapses through phagocytosis,and maintaining homeostasis[1].As a response to CNS injury and disease,quiescent astrocytes are transformed into reactive astrocytes,which usually can be divided into two types:Al and A2[2].Al astrocytes help to drive the death of neurons and oligodendrocytes in neurodegenerative disorders by producing a large number of inflammatory factors and secreted toxins,while A2 astrocytes protect neurons via releasing many neurotrophic factors[3].
基金
supported by the National Natural Science Foundation of China(92049104 and 82103210)
a Research Start-up Project by Hangzhou Normal University(4125C5021920453 and 4125C50220204106).
