摘要
脑小血管病(cerebral small vessel disease,CSVD)是导致血管性认知损害的主要原因,其机制目前尚未完全明确,可能与血管内皮功能障碍以及血脑屏障破坏等因素有关。近年来,针对CSVD患者认知损害的生物标志物进行了一些研究。文章从炎症反应和氧化应激、血管内皮功能障碍、内分泌、神经系统损伤以及微RNA等方面对CSVD患者认知损害的生物标志物进行了综述。
Cerebral small vessel disease(CSVD)is the main cause of vascular cognitive impairment.Its mechanism is not yet fully clear,which may be associated with vascular endothelial dysfunction and the destruction of blood-brain barrier.In recent years,some studies have been conducted on biomarkers of cognitive impairment in patients with CSVD.This article reviews the biomarkers of cognitive impairment in patients with CSVD from the aspects of inflammatory response,oxidative stress,vascular endothelial dysfunction,endocrine,nervous system damage,and microRNAs.
作者
邵云云
郑雪
伏兵
Shao Yunyun;Zheng Xue;Fu Bing(Department of Neurology,the Second People's Hospital of Lianyungang Affiliated to Bengbu Medical College,Lianyungang 222023,China)
出处
《国际脑血管病杂志》
2022年第5期375-379,共5页
International Journal of Cerebrovascular Diseases
基金
连云港市社会发展项目(SF2142)。
关键词
脑小血管疾病
认知障碍
生物标志物
Cerebral small vessel diseases
Cognition disorders
Biomarkers
