摘要
【目的】探讨利奈唑胺联合头孢噻肟钠治疗新生儿化脓性脑膜炎的临床效果及对患儿神经损伤因子、白介素-12(IL-12)、淀粉样蛋白A(SAA)水平的影响。【方法】回顾性分析本院收治的86例新生儿化脓性脑膜炎患儿的临床资料,根据用药方法的不同将其分为观察组和对照组,每组43例。对照组予以头孢噻肟钠治疗,观察组在对照组基础上联合利奈唑胺治疗,均治疗1周。比较两组疗效,治疗前、治疗1周后神经损伤因子[神经元特异性烯醇化酶(NSE)、S100β蛋白]、IL-12、SAA水平、脑脊液蛋白含量、细胞总数、葡萄糖水平,并统计不良反应发生率。【结果】治疗1周后,观察组总有效率为95.35%(41/43),高于对照组的76.74%(33/43),差异有统计学意义(P<0.05);两组血清IL-12、SAA、NSE、S100β蛋白水平均较本组治疗前降低,且观察组均低于对照组(P<0.05);两组脑脊液蛋白含量、细胞总数低于治疗前,葡萄糖水平高于治疗前,且观察组与对照组比较,差异均有统计学意义(P<0.05)。观察组不良反应发生率为13.95%(6/43),低于对照组的6.98%(3/43),但差异无统计学意义(χ^(2)=0.49,P=0.48)。【结论】利奈唑胺联合头孢噻肟钠治疗新生儿化脓性脑膜炎疗效较好,可减轻炎性反应,抑制神经损伤,且具有较好的安全性。
【Objective】To investigate the clinical effect of Linezolid combined with Cefotaxime sodium in the treatment of neonatal purulent meningitis and its effect on the levels of nerve injury factor,interleukin-12(IL-12)and serum amyloid A(SAA).【Methods】The clinical data of 86 newborns with suppurative meningitis treated in our hospital were retrospectively analyzed.According to the different methods of medication,they were divided into observation group and control group,with 43 cases in each group.The control group was treated with cefotaxime sodium,and the observation group was treated with linezolid on the basis of the control group,both of which were treated for one week.The curative effects of the two groups were compared,including the levels of nerve injury factor[neuron specific enolase(NSE),S100β Protein],IL-12,SAA,cerebrospinal fluid protein content,total cell count,glucose level before and 1 week after treatment,and the incidence of adverse reactions was counted.【Results】After one week of treatment,the total effective rate in the observation group was 95.35%(41/43),which was higher than 76.74%(33/43)in the control group,and the difference was statistically significant(P<0.05);The protein levels of serum IL-12,SAA,NSE and S100βin both groups were lower than those before treatmentin,and the observation group was lower than the control group(P<0.05);The protein content and total number of cells in cerebrospinal fluid of the two groups were lower than that before treatment,and the glucose level was higher than that before treatment.The difference between the observation group and the control group was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 13.95%(6/43),lower than 6.98%(3/43)in the control group,but the difference was not statistically significant(χ^(2)=0.49,P=0.48).【Conclusion】Linezolid combined with Cefotaxime sodium is effective in the treatment of neonatal purulent meningitis,which can reduce inflammatory reaction,inhibit nerve injury,and has good safety.
作者
陈伟
董自然
王琴琴
CHEN Wei;DONG Zi-ran;WANG Qin-qin(Shangluo Central Hospital,Shangluo Shaanxi 726000)
出处
《医学临床研究》
CAS
2022年第7期1072-1074,1078,共4页
Journal of Clinical Research
