摘要
免疫和炎症反应是机体对于刺激的一种防御反应,可以分为感染性免疫炎症和非感染性免疫炎症。目前关于免疫炎症在眼部的研究进展主要聚焦在2个方面,一是经典的免疫炎症性眼病的靶向药物或靶点分子治疗研究,二是以往认为的非免疫炎性眼病的免疫机制研究。经典的免疫炎症性眼病如变应性结膜炎、免疫性角膜病变、非感染性葡萄膜炎、视神经炎和甲状腺相关眼病等发病机制中的免疫炎症关键分子是生物治疗的重要靶点。近年来发现在感染性眼病和眼部肿瘤中,免疫炎症机制也有着不可或缺的调控作用。更为重要的是,新近研究揭示免疫炎症在传统观念认为的非炎症性眼病,如近视、青光眼、白内障和年龄相关性黄斑变性等中也发挥了重要的促进作用。因此,免疫炎症广泛参与从眼前段到眼后段疾病的发生和发展过程,通过调控免疫炎症对相关眼病进行免疫治疗的相关研究已引起全球眼科界的重视。眼科医生应关注免疫调控在各种眼科疾病中的作用机制及相关眼病的免疫疗法研究进展,深入探讨免疫炎症调控治疗眼病的新策略,以更好地指导临床实践。
The immune and inflammatory response is a defense response of the body to stimuli and can be divided into infectious and non-infectious immunoinflammatory diseases.Current advances in research on immunoinflammatory in the eye focus on two main areas:research on targeted drugs or targeted molecular therapies for classical immunoinflammatory ocular diseases,and research on the immune mechanisms of previously considered non-immunoinflammatory ocular diseases.Key molecules of immunoinflammation in the pathogenesis of classical ocular immune diseases such as allergic conjunctivitis,immune keratopathy,non-infectious uveitis,optic neuritis,and thyroid-associated ophthalmopathy are important targets for biological therapy.Immunoinflammatory mechanisms have also been found to have an integral regulatory role in infectious ocular diseases and ocular tumors in recent years.More importantly,recent studies have revealed that immunity also plays an important role in the promotion of traditionally considered non-immunoinflammatory ocular diseases such as myopia,glaucoma,cataract,and age-related macular degeneration.Thus,immunoinflammation is widely involved in the development of diseases from the anterior to the posterior segment of the eye,and research related to the immunotherapy of related ocular diseases through the modulation of immunoinflammation has attracted the attention of the global ophthalmic community.Ophthalmologists should pay attention to the mechanisms of immune modulation and the progress of immunotherapy in various ophthalmic diseases,and explore new strategies for better guidelines for the treatment of ocular immunoinflammatory diseases.
作者
陶天玉
苏文如
Tao Tianyu;Su Wenru(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,China)
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2022年第8期701-706,共6页
Chinese Journal Of Experimental Ophthalmology
基金
国家优秀青年科学基金项目(8212200477)
国家重点研发计划项目(2017YFA0105804)。
关键词
免疫
炎症
免疫相关眼病
发病机制
免疫疗法
Immunity
Inflammation
Immune-related eye disease
Pathogenesis
Immunotherapy
