摘要
目的探讨脓肿期肉芽肿性小叶性乳腺炎(GLM)与哺乳期乳腺炎(LM)的中医用药规律及差异。方法筛选自建库至2021年12月发表在中国生物医学文献服务系统、中国知网、万方数据库和维普网中关于中医药治疗脓肿期GLM、LM的文献,应用中医传承计算平台分析脓肿期GLM、LM核心用药及组方规律,并比较两者差异。结果治疗脓肿期GLM、LM的方剂中,前10位高频次药物有7味相同,3味不同。两者四气、五味、归经比较,脓肿期GLM、LM的用药均寒温并用,以苦、甘味药为主。脓肿期GLM的温性、甘味用药占比高于脓肿期LM;两者用药归经均以肝、胃、肺经为主;用药分类中均以清热、补虚、化痰、活血化瘀类药物为主,脓肿期GLM的补虚、化痰、活血化瘀类药物用药占比高于脓肿期LM。进一步分析得到脓肿期GLM潜在药对6个,脓肿期LM潜在药对7个,并各得到一组核心药物组合。结论脓肿期GLM和LM均以清热解毒、托里排脓为治疗原则,脓肿期LM需加强扶正补虚之功,并佐以化痰、活血之品;脓肿期LM则需加强清热凉血之功。
Objective To discuss the medication regularity and difference between abscess stage of granulomatous lobular mastitis(GLM),lactation mastitis(LM).Methods The literatures on traditional Chinese medicine treatment of the abscess stage of GLM,LM published in Sinomed,CNKI,Wanfang Data,and VIP database from inception to December 2021 were screened,to analyze the medication regularity and difference of the abscess stage of GLM,LM through Traditional Chinese Medicine Inheritance Computing Platform.Results The medication regularity of the abscess stage of GLM,LM,seven of the top ten high-frequency drugs were same and three were different.The comparison of the four nature of drugs,five flavours,and channel tropism showed that at the abscess stage of GLM,LM,cold and warm,mainly bitter and sweet taste drugs were used.The proportion of warm and sweet medicine in abscess stage of GLM was higher than that in abscess stage of LM.The main channel tropism were liver,stomach,and lung channels.Drugs for heat-clearing,tonifying deficiency,dissipating phlegm,promoting blood circulation for removing blood stasis were the main drugs in the classification.The proportion of drugs for tonifying deficiency,dissipating phlegm,promoting blood circulation for removing blood stasis in abscess stage of GLM was higher than that in abscess stage of LM.Futher analysis showed that,six potential drug pairs for abscess stage of GLM and seven potential drug pairs for abscess stage of LM were obtained,and a group of core drug combinations were obtained for each.Conclusion Abscess stage of GLM,LM are treated according to the principle of clearing heat and removing toxicity,expelling pathogens by strengthening vital qi and expelling pus.Abscess stage of LM needs to strengthen the function of strengthening vital qi and tonifying deficiency,accompanied by dissipating phlegm and promoting blood circulation products.Abscess stage of LM needs to strengthen the function of heat-clearing and cooling blood.
作者
许继升
刘苗苗
时光喜
梁鸿艺
王博
张梦棣
陈翰翰
李静蔚
XU Jisheng;LIU Miaomiao;SHI Guangxi;LIANG Hongyi;WANG Bo;ZHANG Mengdi;CHEN Hanhan;LI Jingwei(First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China;Department of Breast and Thyroid Surgery,Yanzhou Hospital,Affiliated Hospital of Jining Medical College,Shandong Province,Jining 272100,China;Department of Breast and Thyroid Surgery,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250014,China)
出处
《中国医药导报》
CAS
2022年第23期18-21,31,共5页
China Medical Herald
基金
国家中医药管理局全国中医临床特色技术传承骨干人才培训项目(国中医药人教函〔2019〕36号)
山东省卫生健康委员会齐鲁卫生与健康领军人才培育工程项目(鲁卫人字〔2020〕3号)
山东省中医药科技发展计划项目(2019-0159)。
关键词
肉芽肿性小叶性乳腺炎
哺乳期乳腺炎
脓肿期
用药规律
中医传承计算平台
Granulomatous lobular mastitis
Lactation mastitis
Abscess stage
Medication regularity
Traditional Chinese Medicine Inheritance Computing Platform
