摘要
目的探究游离四碘甲腺原氨酸(FT4)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)联合超声弹性成像对甲状腺结节(TN)良恶性的鉴别价值。方法选取2019年1月至2021年4月于阳光融和医院接受治疗的35例甲状腺恶性肿瘤患者设为恶性组,同时选取同时期60例甲状腺良性结节患者设为良性组。收集两组患者的电子病历信息进行分析,比较两组血清FT4、TPOAb、TgAb浓度以及超声弹性成像参数。结果恶性组血清TPOAb、TgAb浓度大于良性组,FT4浓度低于良性组,差异均有统计学意义(P<0.05)。两组患者的结节大小比较差异无统计学意义(P>0.05)。恶性组患者超声弹性成像参数应变率比值大于良性组,差异有统计学意义(P<0.05)。受试者工作特征曲线(ROC)分析显示,FT4、TPOAb、TgAb、超声弹性成像联合鉴别TN良恶性的敏感度、特异度分别为94.29%、88.33%,曲线下面积(AUC)为0.913,约登指数为0.826(95%CI:0.837~0.961)(P<0.05)。结论FT4、TPOAb、TgAb联合超声弹性成像对TN良恶性具有较高的临床鉴别价值,临床中可结合患者的血清指标以及超声弹性检测鉴别TN良恶性,及时采取正确治疗,改善患者预后。
Objective To explore the value of free tetraiodothyronine(FT4),thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)combined with ultrasound elastography in differential diagnosis of benign and malignant thyroid nodules(TN).Methods Thirty-five patients with malignant thyroid nodules(malignant group)and 60 patients with benign thyroid nodules(benign group)treated in Sunshine Union Hospital from January 2019 to April 2021 were selected.Electronic medical records of the two groups were collected and analyzed.The concentrations of serum FT4,TPOAb and TgAb,and ultrasound elastography parameters in the two groups were compared.Results The concentrations of serum TPOAb and TgAb in the malignant group were higher than those in the benign group,and the concentration of FT4 was lower than that in the benign group,with statistically significant differences(P<0.05).Nodules of the two groups were similar in size(P>0.05),but the strain rate in the malignant group was higher than that in the benign group,with statistically significant differences(P<0.05).The receiver operating characteristic curve(ROC)analysis showed that the sensitivity,specificity and area under curve(AUC)of the combination of FT4,TPOAb,Tg Ab,and ultrasound elastography in differential diagnosis of benign and malignant TNs were94.29%,88.33%,and 0.913,with Youden index of 0.826(95%CI:0.837~0.961).Conclusion FT4,TPOAb and Tg Ab combined with ultrasound elastography has a high differential diagnostic value for benign and malignant thyroid TNs in clinical practice.Clinically,serum indicators can be combined with ultrasonic elastography to diagnose benign and malignant TNs,thereby guiding treatment and improving the prognosis.
作者
韩鹏
胡桂芹
王树艳
HAN Peng;HU Guiqin;WANG Shuyan(Sunshine Union Hospital,Weifang,Shandong,China,261042;Zhucheng People's Hospital,Weifang,Shandong,China,262200)
出处
《分子诊断与治疗杂志》
2022年第8期1367-1370,共4页
Journal of Molecular Diagnostics and Therapy
基金
山东省医药卫生科技发展计划项目(2019WS182)。
