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灯盏花素固体分散体制备工艺筛选 被引量:1

Screening of preparation process of breviscapine solid dispersion
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摘要 目的优选灯盏花素固体分散体最佳制备工艺并对其体外溶出度及含量进行测定。方法以累积溶出率为指标,通过单因素试验,筛选出制备固体分散体的最佳载体及制备方法;并考察药物与载体材料的最佳比例;通过正交试验,筛选灯盏花素固体分散体最佳制备工艺;并对其重现性、溶出度及含量进行考察。结果灯盏花素固体分散体最佳制备载体为泊洛沙姆188;最佳制备方法为熔融法;灯盏花素固体分散体的最佳制备工艺为:药物与载体材料比例为1∶5,熔融温度为70℃,冷却温度为20℃。结论灯盏花素固体分散体能提高其溶解度。 Objective To optimize the preparation process of breviscapine solid dispersion and determine its dissolution in vitro and content.Methods Taking the cumulative dissolution rate as the index,the best carrier and preparation method for preparing solid dispersion were selected through single factor test;the optimal ratio of drug and carrier material was investigated;the optimum preparation process of breviscapine solid dispersion was selected by orthogonal test;the reproducibility,dissolution,and content were investigated.Results The best preparation carrier of breviscapine solid dispersion was poloxamer 188;the best preparation method was melting method;the best preparation process of breviscapine solid dispersion was as follows:the ratio of drug to carrier material was 1∶5,the melting temperature was70℃,and the cooling temperature was 20℃.Conclusion Breviscapine solid dispersion can improve its solubility.
作者 唐婷 李福元 刘艳 邱艳明 TANG Ting;LI Fuyuan;LIU Yan;QIU Yanming(College of Pharmacy,Hunan Traditional Chinese Medicine College,Hunan Province,Zhuzhou,412000,China)
出处 《中国医药导报》 CAS 2022年第24期22-25,共4页 China Medical Herald
基金 湖南省教育厅科学研究项目一般项目(18C1643)。
关键词 灯盏花素 固体分散体 制备工艺 重现性 溶解度 Breviscapine Solid dispersion Preparation process Reproducibility Solubility
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