摘要
利用基因变异作为工具变量来推断暴露与结局关联性的研究称为孟德尔随机化(MR)研究。孟德尔随机化研究报告规范(STROBE-MR)旨在提高MR研究的透明度和报告质量。为更好地理解、传播和应用STROBE-MR报告规范,本文对其进行解读。
Mendelian randomization(MR)studies use genetic variants as instrumental variables to explore the effects of exposures on health outcomes.STROBE-MR(strengthening the reporting of observational studies in epidemiology using Mendelian randomization)assists authors in reporting their MR studies clearly and transparently,and helpfully to improve the quality of MR.This paper interpreted the STROBE-MR,aiming to help Chinese scholars better understand,disseminate,and apply it.
作者
刘明
高亚
杨珂璐
许建国
郑卿勇
赵亮
葛龙
李伦
张俊华
田金徽
LIU Ming;GAO Ya;YANG Kelu;XU Jianguo;ZHENG Qingyong;ZHAO Liang;GE Long;LI Lun;ZHANG Junhua;TIAN Jinhui(Evidence-Based Medicine Center,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,P.R.China;Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province,Lanzhou 730000,P.R.China;Department of Health Research Methods,Evidence and Impact,McMaster University,Hamilton L8S4L8,Canada;Department of Public Health and Primary Care,Academic Centre for Nursing and Midwifery,KU Leuven-University of Leuven,Leuven B-3000,Belgium;School of Nursing,Lanzhou University,Lanzhou 730000,P.R.China;Evidence-Based Social Science Research Center,School of Public Health,Lanzhou University,Lanzhou 730000,P.R.China;Department of Social Science and Health Management,School of Public Health,Lanzhou University,Lanzhou 730000,P.R.China;Department of Breast Cancer,The Second Xiangya Hospital,Central South University,Changsha 410083,P.R.China;Evidence-based Medicine Center of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2022年第8期978-987,共10页
Chinese Journal of Evidence-based Medicine
基金
甘肃省科技计划资助项目(编号:20CX4ZA027、20CX9ZA112)
甘肃省教育厅优秀研究生“创新之星”项目(编号:2021CXZX-141)。
