摘要
目的探讨雄激素受体(androgen receptor,AR)在乳腺癌组织中的表达情况并分析其临床意义。方法选择医院2017年5月—2020年5月收治的女性乳腺癌患者113例,使用免疫组化法检测乳腺癌组织中AR的表达情况,并分析AR阳性率与患者临床特征及肿瘤类型间的相关性。结果113例乳腺癌患者中AR的表达阳性率为46.02%(52/113),AR阳性患者淋巴结转移率更低,同时雌孕激素受体阳性率更高,不同分型乳腺癌患者AR阳性率差异显著,三阴性乳腺癌患者AR阳性率更低。结论乳腺癌组织中AR的阳性表达率较高,AR阳性乳腺癌组织恶性程度更低,预后相对更好,未来AR可能成为治疗乳腺癌的新靶点。
Objective To investigate the expression of androgen receptor(AR)in breast cancer tissues and analyze its clinical significance.Methods 113 female breast cancer patients admitted to our hospital from May 2017 to May 2020 were selected.Immunohistochemistry was used to detect the expression of AR in breast cancer tissues,and the positive rate of AR and the clinical characteristics and tumor types of the patients were analyzed.The correlation between.Results The positive rate of AR expression in 113 patients with breast cancer was 46.02%(52/113).The lymph node metastasis rate of AR positive patients was lower,and the positive rate of estrogen and progesterone receptor was higher.The positive rate of AR in patients with different types of breast cancer was significantly different,and the positive rate of AR in patients with triple negative breast cancer was lower.Conclusion The positive expression rate of AR in breast cancer tissues is higher,and AR-positive breast cancer tissues are less malignant and have a relatively better prognosis.AR may become a new target for the treatment of breast cancer in the future.
作者
张欣
ZHANG Xin(Department of Breast Surgery,Fuzhou No.1 Hospital Affiliated With Fujian Medical University,Fuzhou Fujian 350000,China)
出处
《中国卫生标准管理》
2022年第14期88-91,共4页
China Health Standard Management
关键词
雄激素受体
表达
乳腺癌
临床意义
预后
靶点
androgen receptor
expression
breast cancer
clinical significance
prognosis
target
