摘要
目的分析孕早期女性阴道菌群分布特点及其改变的影响因素。方法采用前瞻性随机试验方法,选择2019年3月至2020年3月浉河区妇幼保健院收治的60例孕早期女性作为研究对象,依据女性阴道菌群分布特点分为阴道菌群紊乱组(11例)与阴道菌群正常组(49例),并收集其基线资料,分析孕早期女性阴道菌群紊乱发生的影响因素。结果60例患者中检出的阴道菌群以乳酸杆菌为阴道优势菌群,占比70.00%(42/60),滴虫占比11.67%(7/60),棒状杆菌占比8.33%(5/60),其他菌群占比10.00%(6/60);60例孕早期女性中阴道菌群紊乱11例,发生率18.33%;将全部可能的影响因素纳入,经单因素分析结果提示,阴道菌群紊乱组患者使用抗生素、阴道pH>4.0、E≤300 pg/mL、阴道清洁度Ⅲ~Ⅳ度、坐浴例数占比高于阴道菌群正常组,差异有统计学意义(P<0.05);Logistic多因素分析结果显示,使用抗生素(β=0.761,OR=3.781)、阴道pH>4.0(β=1.961,OR=7.105)、E≤300 pg/mL(β=1.578,OR=4.846)、阴道清洁度Ⅲ~Ⅳ度(β=2.152,OR=8.600)、坐浴(β=2.091,OR=8.094)均为孕早期女性发生阴道菌群紊乱的独立危险因素,差异有统计学意义(P<0.05)。结论孕早期女性阴道菌群中乳酸杆菌水平较高,棒状杆菌、滴虫水平较低,且使用抗生素、阴道pH>4.0、E≤300 pg/mL、阴道清洁度Ⅲ~Ⅳ度、坐浴均为阴道菌群紊乱发生的独立危险因素,故临床应据此进行合理干预,确保孕早期女性妊娠质量。
Objective To analyze the distribution characteristics and influencing factors of vaginal microbiota in early pregnancy.Methods Using a prospective randomized trial method,60 women in early pregnancy who were admitted to Maternal and Child Health Care Hospital of Shihe District from March 2019 to March 2020 were selected as the research objects.According to the distribution characteristics of female vaginal microbiota,they were divided into the vaginal microbiota disorder group(11cases)and the normal vaginal microbiota group(49 cases),and their baseline data were collected.To analyze the influencing factors of vaginal microbiota disorder in early pregnancy.Results Among the 60 patients,Lactobacillus was the dominant vaginal flora,accounting for 70.00%(42/60),Trichomonas 11.67%(7/60),Corynebacterium 8.33%(5/60),and other flora 10.00%(6/60).Among 60 women in the first trimester,11 cases(18.33%)had vaginal microbiota disorder.All possible influencing factors were included.Univariate analysis results showed that the use of antibiotics,vaginal pH>4.0,E≤300 pg/mL,vaginal cleanlinessⅲ-ⅳ,and the proportion of sitt-bath cases in patients with vaginal microbiota disorder were higher than those in patients with normal vaginal microbiota(P<0.05).The results of Logistic multivariate analysis showed that the use of antibiotics(β=0.761,OR=3.781),vaginal pH>4.0(β=1.961,OR=7.105),E≤300 pg/mL(β=1.578,OR=4.846),vaginal cleanlinessⅢ~Ⅳdegree(β=2.152,OR=8.600)and sitting bath(β=2.091,OR=8.094)were independent risk factors for vaginal microbiota disorder in women in early pregnancy,and the differences were statistically significant(P<0.05).Conclusion Early pregnant women lactobacillus in the vagina flora level is higher,the low level of corynebacterium,trichomoniasis,and use of antibiotics,vaginal pH>4.0,E≤300 pg/mL or less,vaginal cleannessⅢ~Ⅳdegree,sitz bath are independent risk factors for the development of vaginal flora disorder occurs,so the clinical reasonable intervention should be on the basis of ensure the quality of the early pregnant women in pregnancy.
作者
王正勤
WANG Zhengqin(Obstetrics and gynecology,Shihe District Maternal and Child Health Hospital,Xinyang City,Henan Province,Xinyang Henan 464000,China)
出处
《临床研究》
2022年第9期59-62,共4页
Clinical Research
关键词
孕早期
阴道菌群
菌群紊乱
乳酸杆菌
雌激素
early pregnancy
vaginal flora
flora disorder
lactobacillus
estrogen
