摘要
目的探究胃镜下不同给药方法治疗急性非静脉曲张性上消化道出血(ANVUGIB)的差异性。方法研究对象选取为2019年4月至2021年7月之间睢县中医院的96例ANVUGIB患者,根据治疗方法不同分为喷洒组和注射组,每组各48例,喷洒组患者在胃镜下喷洒重酒石酸去甲肾上腺素进行治疗,注射组患者则在胃镜下注射重酒石酸去甲肾上腺素进行治疗,两组患者除给药方式不同外,其他干预方案保持一致,对比两组患者的临床疗效、即刻止血率、1周内再出血率、急诊手术率、平均输血量、平均住院时间、实验室指标和不良反应发生率。结果注射组患者的治疗有效率显著高于喷洒组,即刻止血率显著高于喷洒组,1周内再出血率显著低于喷洒组,差异均有统计学意义(P<0.05)。两组患者的急诊手术率对比,差异无统计学差异(P>0.05)。注射组患者的平均输血量、平均住院时间显著低于喷洒组,血红蛋白及血小板计数均显著高于喷洒组,血尿素氮显著低于喷洒组,差异均有统计学意义(P<0.05)。注射组患者的不良反应发生率与喷洒组对比,差异无统计学意义(P>0.05)。结论相较于胃镜下喷洒给药,胃镜下注射重酒石酸去甲肾上腺素治疗ANVUGIB的疗效更优,能够降低再出血率,减少出血量,缩短住院时间,值得临床应用。
Objective To explore the difference of different administration methods under gastroscope in the treatment of acute non variceal upper gastrointestinal hemorrhage(ANVUGIB).Methods A total of 96 patients with ANVUGIB in Sui Country Hospital of traditional Chinese medicine from April 2019 to July 2021 were selected as the study subjects.According to the different treatment methods,they were divided into spray group and injection group,with 48 patients in each group.The patients in spray group were sprayed with norepinephrine bitartrate under gastroscope for treatment,while the patients in injection group were injected with norepinephrine bitartrate under gastroscope for treatment,the two groups of patients had the same intervention plan except the different way of administration.The clinical efficacy,immediate hemostasis rate,rebleeding rate within one week,emergency operation rate,average blood transfusion volume,average hospitalization time and adverse reaction rate were compared between the two groups.Results The effective rate of the injection group was significantly higher than that of the spray group,the immediate hemostasis rate was significantly higher than that of the spray group,and the rebleeding rate within one week was significantly lower than that of the spray group(P<0.05).There was no significant difference between the two groups in the emergency operation rate(P>0.05).The average blood transfusion volume and average hospitalization time of the injection group were significantly lower than that of the spray group,the hemoglobin and platelet count were significantly higher than that of the spray group,and the blood urea nitrogen was significantly lower than that of the spray group(P<0.05).There was no significant difference in the incidence of adverse reactions between the injection group and the spray group(P>0.05).Conclusion Compared with spraying under gastroscope,norepinephrine bitartrate injection under gastroscope is more effective in the treatment of ANVUGIB,which can reduce the rebleeding rate,reduce the bleeding volume and shorten the hospitalization time,and is worthy of clinical application.
作者
陈慧
CHEN Hui(Department of Gastroenterology,Sui Country Hospital of Traditional Chinese Medicine,Shangqiu Henan 476900,China)
出处
《临床研究》
2022年第9期94-97,共4页
Clinical Research
