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LRRK2在克罗恩病中作用的研究进展

Research progress on role of LRRK2 in Crohn’s disease
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摘要 富亮氨酸重复序列激酶2(LRRK2)是一种作用广泛的多结构域枢纽蛋白。近年来研究发现,LRRK2与克罗恩病(CD)发病高度相关,LRRK2基因或LRRK2蛋白异常可通过调控溶菌酶的分泌、LRRK2蛋白的激酶活性、活性氧的释放、自噬过程、炎性细胞因子的释放等方式在CD的发病过程中发挥着重要作用。该文主要就LRRK2在CD发病过程中作用的研究进展作一综述,以期为CD的诊治提供新思路。
作者 庄文涵 廖雨晗 徐鹏飞 蔡亦斐 叶月芳 ZHUANG Wenhan;LIAO Yuhan;XU Pengfei;CAI Yifei;YE Yuefang
出处 《国际消化病杂志》 CAS 2022年第4期213-217,共5页 International Journal of Digestive Diseases
基金 浙江省自然科学基金(LY16H030017) 2021年浙江省大学生科技创新活动计划暨新苗人才计划项目(2021R426050)。
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