摘要
目的 分析创伤性脑损伤患者进行血清S100B检测对评估伤重程度及患者预后情况的价值。方法 选择2019年6月—2021年9月江苏省张家港市第一人民医院收治的72例创伤性脑损伤患者为研究对象,根据患者入院时格拉斯哥昏迷评分(Glasgow Coma Scale,GCS)划分3组,即轻度组(24例)、中度组(24例)、重度组(24例),均进行血清S100B检测。比较3组患者入院后1、3、5 d血清S100B检测结果差异。同时对患者进行为期3个月的跟踪随访,评估患者预后GSC评分,根据结果划分两组,即预后良好组(36例)、预后不良组(36例),同样对比分析两组患者入院后1、3、5 d血清S100B检测结果差异。结果 创伤性脑损伤轻度、中度组患者随着治疗进度血清S100B检测结果均呈现下降趋势,重度组患者呈现升高趋势。轻度组患者入院后1 d血清S100B检测结果(1.05±0.25)μg/L、3 d血清S100B检测结果为(0.66±0.18)μg/L及5 d血清S100B检测结果(0.49±0.15)μg/L明显低于中度组与重度组患者,差异有统计学意义(F=26.135、148.107、113.836,P<0.05),同时预后良好组患者入院后1、3、5 d血清S100B检测结果明显低于预后不良组患者,差异有统计学意义(P<0.05)。结论 临床可通过检测血清S1000B指标反映创伤性脑损伤患者病情程度及预后情况,准确性较高,提倡运用推广。
Objective To analyze the value of serum S100B detection in patients with traumatic brain injury in evaluating the severity of injury and the prognosis of Jiangsu Province patients.Methods 72 patients with traumatic brain injury admitted to the First People’s Hospital of Zhangjiagang City,Jiangsu Province from June 2019 to September 2021 were selected as the research subjects.Patients were divided into 3 groups according to Glasgow Coma Scale(GCS) at admission,namely mild group(24 cases),moderate group(24 cases),and severe group(24 cases),all of which were tested for serum S100B.The differences in serum S100B detection results were compared among the three groups at 1 d,3 d,and 5 d after admission.At the same time,the patients were followed up for 3 months to evaluate the GSC score of the patients’ prognosis.According to the results,they were divided into two groups,namely the good prognosis group(36 cases) and the poor prognosis group(36 cases).The differences in serum S100B detection results were also compared between the two groups at 1 d,3 d,and 5 d after admission.Results With the progress of treatment,serum S100B test results showed a downward trend in patients with mild and moderate traumatic brain injury,and an increase trend in patients with severe trauma.The serum S100B test results of the mild group patients after admission were(1.05±0.25) μg/L,the serum S100B test results on the 3rd day(0.66±0.18) μg/L and the serum S100B test results on the 5th day(0.49±0.15) μg/L were significantly lower than those of patients in moderate group and severe group,the difference was statistically significant(F=26.135,148.107,113.836,P<0.05).At the same time,the serum S100B detection results of the patients in the good prognosis group at 1 d,3 d,and 5 d after admission were significantly lower than those in the poor prognosis group,the difference was statistically significant(P<0.05).Conclusion Serum S1000B index can be used to reflect the severity and prognosis of patients with traumatic brain injury in clinical practice,with high accuracy,and its application and promotion are recommended.
作者
芮琴
倪海波
RUI Qin;NI Haibo(Department of Laboratory Medicine,Zhangjiagang First People's Hospital,Zhangjiagang,Jiangsu Province,215600 China;Department of Neurosurgery,Zhangjiagang First People's Hospital,Zhangjiagang,Jiangsu Province,215600 China)
出处
《系统医学》
2022年第14期18-21,共4页
Systems Medicine
基金
苏州市临床重点病种诊疗专项(LCZX201821)。
