摘要
目的 探讨凝血酶原时间与血小板参数在肝硬化患者中的检验价值。方法 从2018年1月—2021年5月盐城市大丰中医院收治肝硬化患者中抽取60例为观察组,同期60名健康体检志愿者为对照组,采集两组静脉血样测定凝血指标凝血酶原时间(PT)与血常规五分类中血小板参数血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV),比较观察两组指标差异以及观察组不同肝硬化分期患者的指标差异,评价5项指标诊断肝硬化的效能。结果 观察组PT(16.32±2.83)s,PLT(92.85±14.51)×10~9/L、PCT(0.10±0.04)%、MPV(10.97±2.03)fl,与对照组对比,差异有统计学意义(t=11.140、14.797、8.593、6.387,P<0.05)。PT、PLT、PCT、MPV指标联合诊断肝硬化的灵敏度为96.67%、符合率为92.50%,均高于单一诊断,差异有统计学意义(P<0.05)。观察组失代偿患者PT(18.68±2.57)s,PLT(83.15±9.84)×10~9/L、PCT(0.07±0.02)%、MPV(12.04±2.35)fl,与代偿患者对比,差异有统计学意义(t=5.799、6.882、6.575、3.376,P<0.05)。结论 PT与血小板参数PLT、PCT、MPV的检验可以为临床诊断肝硬化提供有价值的实验室依据,联合应用能够提高诊断灵敏度,亦能为判断肝硬化患者病情严重程度提供参考。
Objective To investigate the value of prothrombin time and platelet parameters in patients with cirrhosis.Methods From January 2018 to May 2021,60 patients with liver cirrhosis admitted to Yancheng Dafeng Hospital of Traditional Chinese Medicine Yancheng were selected as the observation group.During the same period,60 healthy volunteers were selected as the control group.Two groups of venous blood samples were collected to determine the coagulation index prothrombin time(PT) and platelet parameters platelet count(PLT),platelet volume(PCT) and mean platelet volume(MPV) in the five categories of blood routine.The differences of indexes between the two groups and the indexes of patients with different stages of cirrhosis in the observation group were compared,and the efficacy of the five indexes in diagnosing cirrhosis was evaluated.Results In observation group,PT(16.32±2.83)s,PLT(92.85±14.51)×10~9/L,PCT(0.10±0.04)%,MPV(10.97±2.03)fl,compared with the control group,the difference was statistically significant(t=11.140,14.797,8.593,6.387,P<0.05).The sensitivity of PT,PLT,PCT and MPV in the diagnosis of liver cirrhosis was 96.67% and the coincidence rate was 92.50%,which were higher than single diagnosis,the difference was statistically significant(P<0.05).Decompensated patients in observation group had PT(18.68±2.57)s,PLT(83.15±9.84)×10~9/L,PCT(0.07±0.02)%,MPV(12.04±2.35)fl,compared with the compensated patients,the difference was statistically significant(t=5.799,6.882,6.575,3.376,P<0.05).Conclusion The detection of PT and platelet parameters PLT,PCT,MPV can provide valuable laboratory basis for clinical diagnosis of liver cirrhosis.The combined application can improve the diagnostic sensitivity and provide reference for judging the severity of liver cirrhosis patients.
作者
朱晓庆
ZHU Xiaoqing(Department of Laboratory,Yancheng Dafeng Hospital of Traditional Chinese Medicine Yancheng,Jiangsu Province,224100 China)
出处
《系统医学》
2022年第14期63-66,共4页
Systems Medicine
