摘要
目的 探讨血清肿瘤坏死因子-α(TNF-α)表达与子宫内膜异位症(EMT)患者手术前后卵巢储备功能、EMT标志物的相关性。方法 选取2018年1月至2020年4月江苏省南通市海安人民医院妇产科收治的92例EMT患者为研究对象。分析手术前后血清TNF-α表达与EMT患者临床特征的关系,对比不同美国生育协会标准(R-AFS)分期患者手术前后卵巢储备功能[抗缪勒氏管激素(AMH)、雌二醇(E2)]、EMT标志物[糖类抗原125(CA-125)、抗子宫内膜抗体(EMAb)],分析血清TNF-α表达与卵巢储备功能及EMT标志物的相关性,Logistic回归分析术后复发影响因素。结果 手术前后血清TNF-α表达均与R-AFS分期呈正相关(P<0.05);不同R-AFS分期患者术后血清AMH水平高于术前,血清E2、CA-125、EMAb水平低于术前(P<0.05);术前血TNF-α表达与AMH呈负相关,与E2呈正相关(P<0.05);手术前后血清TNF-α表达与CA-125、EMAb呈正相关(P<0.05);Logistic回归分析显示,校正R-AFS分期后,手术前后TNF-α、EMAb、CA-125高表达均为EMT患者术后复发的独立危险因素(P<0.05)。结论 EMT患者血清TNF-α异常高表达,与R-AFS分期、卵巢储备功能、EMT标志物(CA-125、EMAb)有关,且手术前后血清TNF-α、CA-125、EMAb高表达均为术后复发的独立危险因素。
Objective To explore the correlation between serum tumor necrosis factor-α(TNF-α)expression and ovarian reserve function and EMT markers before and after surgery in patients with endometriosis(EMT).Methods A total of 92 EMT patients in the hospital,from January 2018 to April 2020 were selected as the research objects.The relationship between the expression of serum TNF-αbefore and after surgery and the clinical characteristics of EMT patients were analyzed.The ovarian reserve function[Antimullerian hormone(AMH),Estradiol(E2)],EMT Markers[Carbohydrate Antigen 125(CA-125),Anti-Endometrial Antibody(EMAb)]before and after surgery in patients with different R-AFS stages were compared.The correlation between serum TNF-αexpression,ovarian reserve and EMT markers were analyzed.Logistic regression model was used to analyze the influencing factors of postoperative recurrence.Results The expression of serum TNF-αbefore and after the operation was positively correlated with the American Fertility Association standard(R-AFS)staging(P<0.05);The postoperative serum AMH levels of the patients with different R-AFS stages were higher than those before the operation,and the serum E2,CA-125,and EMAb levels were lower than those before the operation(P<0.05);Preoperative serum TNF-αexpression was negatively correlated with AMH,and positively correlated with E2(P<0.05);The expression of serum TNF-αbefore and after surgery was positively correlated with CA-125 and EMAb(P<0.05);Logistic regression analysis showed that after correcting R-AFS staging,the high expressions of TNF-α,EMAb and CA-125 before and after surgery were independent risk factors for postoperative recurrence in EMT patients(P<0.05).Conclusion Serum TNF-αwas abnormally high in EMT patients,and it was related to R-AFS staging,ovarian reserve,EMT markers(CA-125,EMAb).And the high expression of serum TNF-α,CA-125 and EMAb before and after surgery are independent risk factors for postoperative recurrence.
作者
朱静
张译心
王吕
陆月梅
王秀美
ZHU Jing;ZHANG Yixin;WANG Lv;LU Yuemei;WANG Xiumei(Department of Obstetrics and Gynecology,Haian People's Hospital of Nantong City,Nantong Jiangsu 226600,China)
出处
《新疆医科大学学报》
CAS
2022年第8期841-847,共7页
Journal of Xinjiang Medical University
基金
江苏省软科学研究计划项目(183920932)。