摘要
目的了解1990—2019年中国人群白血病疾病负担变化趋势和危险因素分析,为白血病预防提供新思路。方法利用2019年全球疾病负担(Global Burden of Disease,GBD)研究数据通过Joinpoint Regression Program进行回归分析,计算白血病发病率、死亡率、伤残调整寿命年(disability adjusted life year,DALY)、早死损失健康寿命年(tears of life lost,YLL)、伤残损失健康寿命年(years lived with disability,YLD)及其相应的年龄标化率,并与全球和各级社会人口指数(socio-demographic index,SDI)国家对比;计算平均年度变化百分比(average annual percentage of change,AAPC)反映疾病负担变化趋势;计算归因于各危险因素所致疾病负担变化情况。结果1990—2019年中国白血病发病率由12.06/10万降低至10.87/10万,死亡率由5.65/10万降低至4.25/10万,DALY率由328.95/10万降低至162.36/10万;标化发病率、标化死亡率、标化DALY率均呈逐年下降趋势,AAPC分别为-0.6%、-1.8%、-2.4%;2019年中国白血病疾病负担高于全球平均水平,标化DALY率和标化YLL率在各级SDI国家中最高;青少年和儿童疾病负担指标下降幅度最大;吸烟在所收集的四种危险因素中占主要地位,身体质量指数(Body Mass Index,BMI)升高也是重要危险因素之一。结论1990—2019年中国白血病疾病负担总体呈下降趋势,吸烟是白血病的主要危险因素,目前中国白血病疾病负担仍处于较高水平,应针对重点人群加强干预。
Objective To investigate the trend and risk factors of leukemia disease burden in Chinese population from 1990 to 2019,and to provide new ideas for leukemia prevention.Methods The Global Burden of Disease(GBD)study data in 2019 were used for regression analysis through Joinpoint Regression Program.The leukemia incidence,mortality,disability adjusted life year(DALY),years of life lost(YLL),years lived with disability(YLD)and their corresponding age standardized rates were calculated and compared with global level and all Socio–Demographic Index(SDI)countries.Average annual percentage of change(AAPC)was calculated to reflect the trend of disease burden.The changes in disease burden attributable to each risk factor were calculated.Results From 1990 to 2019,the incidence of leukemia in China decreased from 12.06/100000 to 10.87/100000,the mortality decreased from 5.65/100000 to 4.25/100000,and the DALY rate decreased from 328.95/100000 to 162.36/100000.The standardized incidence,standardized mortality and standardized DALY rates all decreased year by year,with AAPC being 0.6%,1.8%,and 2.4%,respectively.In 2019,the disease burden of leukemia in China was higher than the global average,and the standardized DALY rate and standardized YLL rate were the highest among all SDI countries.Adolescents and children had the greatest decline in the disease burden index.Smoking was the main risk factor among the four risk factors collected,and the increase of body mass index(BMI)was also one of the important risk factors.Conclusion From 1990 to 2019,the disease burden of leukemia in China generally showed a downward trend.Smoking is the main risk factor of leukemia.At present,the disease burden of leukemia in China is still at a high level,and intervention should be strengthened for key populations.
作者
喻静
姜海虹
刘欢
刘歌
毕勇毅
刘娜娜
金运钦
王红
YU Jing;JIANG Hai-hong;LIU Huan;LIU Ge;BI Yong-yi;LIU Na-na;JIN Yun-qin;WANG Hong(School of Public Health,Wuhan University,Wuhan,Hubie 430071,China)
出处
《公共卫生与预防医学》
2022年第5期23-28,共6页
Journal of Public Health and Preventive Medicine
