摘要
铁超载作为许多神经系统疾病的病理性特征,可引起氧化应激反应,导致神经细胞铁代谢异常。缺氧诱导因子(HIF)可通过调控脑铁的摄取、储存、排出和胞内调节等过程参与脑铁代谢,抑制脑铁超载有望成为神经系统疾病治疗的新靶点。本文现围绕HIF调控脑铁代谢的生理/病理机制综述如下,以期为相关神经系统疾病的治疗提供新的思路和方法。
Iron overload,as a pathological feature of many nervous system diseases,can cause oxidative stress and lead to abnormal iron metabolism and injury of nerve cells.Hypoxia inducible factor(HIF)can participate in brain iron metabolism by regulating brain iron uptake,storage,excretion and intracellular regulation.So,HIF is expected to become a therapeutic target to inhibit brain iron overload in nervous system diseases.This paper reviews the physiological/pathological mechanism of HIF in regulating brain iron metabolism,in order to provide new treatment ideas and methods for nervous system diseases characterized by brain iron overload.
作者
张智威
张天蕾
方明楚
林心如
李海哲
林振浪
Zhang Zhiwei;Zhang Tianlei;Fang Mingchu;Lin Xinru;Li Haizhe;Lin Zhenlang(Second Clinical Medical College,Wenzhou Medical University,Wenzhou 325006,China;Department of Pediatrics,Second Affiliated Hospital of Wenzhou Medical University and Yuying Children's Hospital,Wenzhou 325006,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2022年第8期843-846,共4页
Chinese Journal of Neuromedicine
关键词
脑铁代谢
脑铁超载
缺氧诱导因子
神经系统
氧化应激
Brain iron metabolism
Brain iron overload
Hypoxia inducible factor
Nervous system
Oxidative stress
