摘要
目的分析复方甘草酸苷+小剂量阿维A对红皮病型银屑病的疗效。方法选取2020年10月—2021年10月解放军第九七〇医院烟台院区收治的82例红皮病型银屑病患者为研究对象,入院后以抽签分为单一组和联合组,每组41例,前者行小剂量阿维A治疗,后者行复方甘草酸苷+小剂量阿维A,分析两组恢复情况、皮肤屏障功能,统计有效率和不良事件。结果用药前,两组皮损面积及PASI评分对比,差异无统计学意义(t=0.239、0.375,P>0.05)。用药后联合组的皮损面积以及PASI评分均低于单一组,差异有统计学意义(t=7.600、8.069,P<0.001)。用药前,两组皮脂含量以及皮肤含水量对比,差异无统计学意义(t=0.701、0.229,P>0.05)。用药后,联合组皮脂含量以及皮肤含水量高于单一组,差异有统计学意义(t=5.291、4.402,P<0.001)。联合组有效率为95.12%,高于单一组的75.61%,差异有统计学意义(χ^(2)=6.248,P<0.05)。联合组的不良反应率为2.44%,低于单一组的19.51%,差异有统计学意义(χ^(2)=4.493,P<0.05)。结论复方甘草酸苷+小剂量阿维A对红皮病型银屑病的疗效显著,能增强皮肤屏障功能,加速皮肤病变的恢复,有效性高。
Objective To analyse the efficacy of compound glycyrrhizin+low-dose acitretin on erythrodermic psoriasis.Methods From October2020 to October 2021,82 patients with erythrodermic psoriasis admitted to the 970th Hospital of the People′s Liberation Army,Yantai Branch were selected as the research objects.After admission,they were divided into a single group and a combined group by lottery,with 41cases in each group.The former was treated with low-dose avid A,while the latter received compound glycyrrhizin+low-dose avid A,and the recovery,skin barrier function,statistical efficiency and adverse events were analysed between the two groups.Results Before drug administration,the skin lesion area and the PASI score were compared between the two groups,the difference was not statistically significant(t=0.239,0.375,P>0.05).After treatment,the skin lesion area and PASI score of the combined group were lower than those of the single group,and the difference was statistically significant(t=7.600,8.069,P<0.001).Before medication,Before medication,the sebum content and skin water content of the two groups were compared,the difference was not statistically significant(t=0.701,0.229,P>0.05).After medication,the sebum content and skin water content in the combined group were higher than those in the single group,and the difference was statistically significant(t=5.291,4.402,P<0.001).The effective rate of the combined group was 95.12%higher than that of the single group,75.61%,and the difference was statistically significant(χ2=6.248,P<0.05).The adverse reaction rate of the combined group was 2.44%lower than that of the single group,19.51%,and the difference was statistically significant(χ2=4.493,P<0.05).Conclusion Compound glycyrrhizin+low-dose avi A is highly effective in erythroderma psoriasis,can enhance the skin barrier function,accelerate the recovery of skin lesions,and has high effectiveness.
作者
杨道秋
姜岩峰
YANG Daoqiu;JIANG Yanfeng(Department of Dermatology,the 970th Hospital of the People′s Liberation Army,Yantai Branch,Yantai,Shandong Province,264002 China;Blood Donation Service Department,Yantai Central Blood Station,Yantai,Shandong Province,264000 China)
出处
《世界复合医学》
2022年第8期174-177,共4页
World Journal of Complex Medicine
