摘要
目的:观察健脾化积扶正汤对原发性肝癌患者细胞免疫功能与生活质量的影响。方法:将101例原发性肝癌患者按随机对照法分为研究组50例与对照组51例,对照组常规治疗,研究组在对照组基础上使用健脾化积扶正汤治疗。比较2组临床疗效;记录并比较2组治疗前后成熟T淋巴细胞(CD3^(+))、诱导性T细胞(CD4^(+))、细胞毒性T细胞(CD8^(+))、免疫球蛋白G(IgG)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(STB)、癌胚抗原(CEA)、肿瘤标志物甲胎蛋白(AFP)及中医证候积分的变化;使用生活质量评价量表(SF-36)评价2组治疗前后生活状况。结果:研究组治疗总有效率74.00%,高于对照组52.94%(P<0.05)。与同组治疗前比较,治疗后2组CD4^(+)、IgG、SF-36各项评分均升高(P<0.05),CD8^(+)、AST、ALT、STB、CEA、AFP水平与肝区疼痛、嗳气纳呆、腹泻、失眠等中医证候积分均降低(P<0.05);与对照组治疗后比较,研究组治疗后CD3^(+)、CD4^(+)、IgG、SF-36各项评分均较高(P<0.05),CD8^(+)、AST、ALT、STB、CEA、AFP水平与肝区疼痛、嗳气纳呆、腹泻、失眠等中医证候积分均较低(P<0.05)。结论:健脾化积扶正汤治疗原发性肝癌,可有效改善患者免疫功能,提高生活质量及临床疗效,并改善患者肝功能指标,降低肿瘤标志物含量。
Objective:To observe the effect of the therapy of Jianpi Huaji Fuzheng tang on cellular immune function and quality of life in patients with primary liver cancer.Methods:A total of 101 patients with primary liver cancer were divided into the study group and the control group according to the randomized control method,with 50 and 51 cases in each group respectively.The control group was treated with routine treatment,and the study group was additionally treated with Jianpi Huaji Fuzheng tang based on the treatment of the control group.The clinical effects were compared between the two groups;before and after treatment,the changes of mature T lymphocytes(CD3^(+)),inducible T lymphocytes(CD4^(+)),cytotoxic T lymphocytes(CD8^(+)),immunoglobulin G(IgG),aspartate aminotransferase(AST),alanine aminotransferase(ALT),serum total bilirubin(STB),carcinoembryonic antigen(CEA),alpha-fetoprotein(AFP)and Chinese medicine syndrome scores in the two groups were recorded and compared.Before and after treatment,the living conditions in the two groups were evaluated by Short Form-36(SF-36)for quality of life.Results:The total effective rate was 74.00%in the study group,higher than that of 52.94%in the control group(P<0.05).After treatment,the scores of CD4^(+),IgG and SF-36 in the two groups were increased when compared with those before treatment(P<0.05),and the levels of CD8^(+),AST,ALT,STB,CEA and AFP and the Chinese medicine syndrome scores of pain in the liver area,belching,poor appetite and digestion,diarrhea and insomnia were decreased;after treatment,the scores of CD3^(+),CD4^(+),IgG and SF-36 in the study group were higher than those in the control group(P<0.05),and the levels of CD8^(+),AST,ALT,STB,CEA and AFP and the Chinese medicine syndrome scores of pain in the liver area,belching,poor appetite and digestion,diarrhea and insomnia in the study group were lower(P<0.05).Conclusion:The therapy of Jianpi Huaji Fuzheng tang for primary liver cancer can effectively improve the immune function of patients,enhance the quality of life and clinical effect,improve the indexes of the liver function of patients,and reduce the content of tumor markers.
作者
方根新
崔一怡
FANG Genxin;CUI Yiyi
出处
《新中医》
CAS
2022年第15期158-162,共5页
New Chinese Medicine
关键词
原发性肝癌
健脾化积扶正汤
免疫功能
生活质量
Primary liver cancer
Jianpi Huaji Fuzheng tang
Immune function
Quality of life
