摘要
骨质疏松症是一种常见的代谢性骨病, 其病理机制是正常骨重塑过程被破坏, 骨吸收大于骨形成。成骨细胞和破骨细胞对维持骨稳态起着关键作用。近年来, 越来越多的研究发现免疫细胞通过释放各种趋化因子和细胞因子参与成骨细胞和破骨细胞活性的调节, 并据此提出免疫性骨质疏松的概念。本文旨在综述骨质疏松中免疫系统作用的研究进展, 展望骨免疫学的未来发展前景, 以便更好地从免疫学角度去研究和防治骨质疏松。
Osteoporosis is a common metabolic bone disease,which is involved in disrupted normal bone remodeling process and bone resorption exceeding bone formation.Osteoblasts and osteoclasts play critical roles in maintaining bone homeostasis.In recent years,more and more studies have found that immune cells are involved in the regulation of osteoblast and osteoclast activity via releasing various chemokines and cytokines,and the concept of immunoporosis has been proposed accordingly.This article summarizes the current state of knowledge on the immune system in the pathophysiology of osteoporosis,so as to study and prevent osteoporosis from the perspective of immunology.
作者
蔡俊民
周后德
Cai Junmin;Zhou Houde(National Clinical Research Center for Metabolic Diseases,Hunan Provincial Key Laboratory for Metabolic Bone Diseases,Department of Metabolism and Endocrinology,the Second Xiangya Hospital of Central South University,Changsha 410011,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2022年第7期558-566,共9页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金(82170900、81970762、81770880)
湖南省科技厅基金项目(2020SK2080)。
