摘要
目的 探讨丙戊酸钠联合喹硫平治疗双相情感障碍躁狂发作的临床疗效。方法 将52例双相情感障碍躁狂发作患者按照治疗方法不同分为研究组与对照组,各26例。两组均给予丙戊酸钠治疗,研究组联合喹硫平治疗。治疗前后采用蒙哥马利抑郁量表、杨氏躁狂量表、总体印象量表-双相情感障碍版评定两组患者的抑郁症状、躁狂症状及抑郁与躁狂交替发作症状,比较两组临床疗效及不良反应发生率。结果 治疗后两组蒙哥马利抑郁量表、杨氏躁狂量表、总体印象量表-双相情感障碍版评分均较治疗前显著降低(P<0.01),研究组显著低于对照组(P<0.01)。研究组治疗总有效率显著高于对照组(P<0.05),两组不良反应发生率比较差异无统计学意义(P>0.05)。结论 丙戊酸钠联合喹硫平治疗双相情感障碍躁狂发作的临床疗效满意,能显著改善患者的抑郁、躁狂等临床症状,安全性高。
Objective To investigate the clinical efficacy of sodium valproate combined with quetiapine in the treatment of manic episodes of bipolar disorder.Methods A total of 52 patients with manic episodes of bipolar disorder were divided into study group and control group according to different treatment methods,with 26 cases in each group.Both groups were treated with sodium valproate,and the study group was treated with quetiapine.Before and after treatment,the Montgomery-Asberg depression rating scale(MADRS),Young mania rating scale(YMRS)and clinical global impression-bipolar disorder(CGI-BP)were used to evaluate the depressive symptoms,manic symptoms and alternating episodes of depression and mania in the two groups.The clinical efficacy and incidence of adverse reactions were compared between the two groups.Results After treatment,the scores of MADRS,YMRS and CGI-BP in the two groups were significantly lower than those before treatment(P<0.01),and the study group was significantly lower than the control group(P<0.01).The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05),and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions The clinical efficacy of sodium valproate combined with quetiapine in the treatment of manic episodes of bipolar disorder is satisfactory,and it can significantly improve the clinical symptoms of depression and mania,with high safety.
作者
杨冬升
胡怀奎
智来
Yang Dongsheng;Hu Huaikui;Zhi Lai(Psychiatric Hospital of Yandu District,Yancheng City,Yancheng 224011,Jiangsu,China)
出处
《临床心身疾病杂志》
CAS
2022年第5期139-141,共3页
Journal of Clinical Psychosomatic Diseases
关键词
双相情感障碍躁狂发作
喹硫平
丙戊酸钠
临床疗效
安全性
manic episodes of bipolar disorder
quetiapine
sodium valproate
clinical efficacy
safety
